Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacT-ataR/DUF1778(antitoxin) |
| Location | 732545..733302 | Replicon | chromosome |
| Accession | NZ_CP082954 | ||
| Organism | Salmonella enterica subsp. arizonae strain S499 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | - |
| Locus tag | K8I78_RS03510 | Protein ID | WP_080169396.1 |
| Coordinates | 732545..733027 (-) | Length | 161 a.a. |
Antitoxin (Protein)
| Gene name | ataR | Uniprot ID | A0A5Y0S3F2 |
| Locus tag | K8I78_RS03515 | Protein ID | WP_001750501.1 |
| Coordinates | 733018..733302 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8I78_RS03465 (728073) | 728073..728528 | + | 456 | WP_063390820.1 | hypothetical protein | - |
| K8I78_RS03470 (728531) | 728531..728752 | + | 222 | WP_063390984.1 | helix-turn-helix transcriptional regulator | - |
| K8I78_RS03475 (728786) | 728786..728965 | - | 180 | WP_077950812.1 | hypothetical protein | - |
| K8I78_RS03480 (729608) | 729608..729757 | + | 150 | Protein_683 | DNA-binding protein | - |
| K8I78_RS03485 (729901) | 729901..730074 | + | 174 | WP_223556138.1 | topoisomerase DNA-binding C4 zinc finger domain-containing protein | - |
| K8I78_RS03490 (730774) | 730774..731238 | + | 465 | WP_079899838.1 | STY4534 family ICE replication protein | - |
| K8I78_RS03495 (731331) | 731331..731549 | + | 219 | WP_001750504.1 | hypothetical protein | - |
| K8I78_RS03500 (731562) | 731562..732065 | + | 504 | WP_088759582.1 | single-stranded DNA-binding protein | - |
| K8I78_RS03505 (732234) | 732234..732350 | + | 117 | WP_223556142.1 | Rpn family recombination-promoting nuclease/putative transposase | - |
| K8I78_RS03510 (732545) | 732545..733027 | - | 483 | WP_080169396.1 | GNAT family N-acetyltransferase | Toxin |
| K8I78_RS03515 (733018) | 733018..733302 | - | 285 | WP_001750501.1 | DUF1778 domain-containing protein | Antitoxin |
| K8I78_RS03520 (733692) | 733692..734096 | + | 405 | WP_223555897.1 | hypothetical protein | - |
| K8I78_RS03525 (734093) | 734093..734710 | + | 618 | WP_223555900.1 | toxin co-regulated pilus biosynthesis Q family protein | - |
| K8I78_RS03530 (734753) | 734753..734944 | + | 192 | Protein_693 | hypothetical protein | - |
| K8I78_RS03535 (735351) | 735351..735821 | + | 471 | WP_079899802.1 | universal stress protein | - |
| K8I78_RS03540 (735889) | 735889..736104 | + | 216 | Protein_695 | transposase | - |
| K8I78_RS03545 (736577) | 736577..736987 | - | 411 | WP_140711285.1 | hypothetical protein | - |
| K8I78_RS03550 (737966) | 737966..738187 | + | 222 | Protein_697 | antiterminator Q family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 723028..821380 | 98352 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 161 a.a. Molecular weight: 18082.84 Da Isoelectric Point: 7.4139
>T215689 WP_080169396.1 NZ_CP082954:c733027-732545 [Salmonella enterica subsp. arizonae]
MEINVTAPELLNEEHILQSFDCGNDVLNDWLRRRAMKNQHLNASRTFVICLECTKRVVGYYSIATGSISHIDLGRSLRHN
MPDPVPVVLLGRLAIDKCTQGHHFGKWLLNDAVTRVSNLAGQVGIKAIMVHAIDEQAKEFYEYFGFVQSPVAPNTLFYKI
MEINVTAPELLNEEHILQSFDCGNDVLNDWLRRRAMKNQHLNASRTFVICLECTKRVVGYYSIATGSISHIDLGRSLRHN
MPDPVPVVLLGRLAIDKCTQGHHFGKWLLNDAVTRVSNLAGQVGIKAIMVHAIDEQAKEFYEYFGFVQSPVAPNTLFYKI
Download Length: 483 bp
>T215689 NZ_CP110892:158801-159106 [Citrobacter freundii]
ATGCAGTTTAAGGTTTACGCCTATAAAAGAGAAAGCCGCTACCGTCTGTTCGTCGACGTGCAGAGTGACATTATTGACAC
CCCGGGACGCCGGATGGTGATCCCGCTGGTCAGCGCCCGCCTGCTGTCCGACAAAGTCTCGCGTGAGCTTTATCCGGTGG
TGTCAGTCGGAGGTGACCCTTATCGTCTGATGACCACGGATATGGCCAGTGTGCCGGCCACTGTCATCGGGGAAGAAGTG
GCCGATCTCAGCCACCTGGAGAATGACATCCAGAACGCCATCAACCTGATGTTCCGGGGGATCTGA
ATGCAGTTTAAGGTTTACGCCTATAAAAGAGAAAGCCGCTACCGTCTGTTCGTCGACGTGCAGAGTGACATTATTGACAC
CCCGGGACGCCGGATGGTGATCCCGCTGGTCAGCGCCCGCCTGCTGTCCGACAAAGTCTCGCGTGAGCTTTATCCGGTGG
TGTCAGTCGGAGGTGACCCTTATCGTCTGATGACCACGGATATGGCCAGTGTGCCGGCCACTGTCATCGGGGAAGAAGTG
GCCGATCTCAGCCACCTGGAGAATGACATCCAGAACGCCATCAACCTGATGTTCCGGGGGATCTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 11033.58 Da Isoelectric Point: 8.5171
>AT215689 WP_001750501.1 NZ_CP082954:c733302-733018 [Salmonella enterica subsp. arizonae]
MQTTTRKSIRNKQINIRATDEERAVIDYAAKLVSKNRTDFIIEKAVNEAQNIILDQRVFVLDDARYQAFIEQLEAPVQNV
EGRQRLMDVKPEWK
MQTTTRKSIRNKQINIRATDEERAVIDYAAKLVSKNRTDFIIEKAVNEAQNIILDQRVFVLDDARYQAFIEQLEAPVQNV
EGRQRLMDVKPEWK
Download Length: 285 bp
>AT215689 NZ_CP110892:158581-158799 [Citrobacter freundii]
GTGAAGCAGCGTATTACAGTGACAGTGGACAGCGACAGCTATCAGTTGCTCAAGGCATACGACGTAAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGCGCCGAACGCTGGCAGGAAGAAAACCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATCGAGGCTAACGGATCGTTTGCTGACGAAAACAGGGACTGGTGA
GTGAAGCAGCGTATTACAGTGACAGTGGACAGCGACAGCTATCAGTTGCTCAAGGCATACGACGTAAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGCGCCGAACGCTGGCAGGAAGAAAACCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATCGAGGCTAACGGATCGTTTGCTGACGAAAACAGGGACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|