Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1714130..1714809 Replicon chromosome
Accession NZ_CP082952
Organism Acinetobacter baumannii strain Cl300

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag K9C16_RS08200 Protein ID WP_000838146.1
Coordinates 1714130..1714312 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag K9C16_RS08205 Protein ID WP_000966688.1
Coordinates 1714405..1714809 (+) Length 135 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9C16_RS08165 (K9C16_08150) 1709428..1709796 + 369 WP_025468552.1 hypothetical protein -
K9C16_RS08170 (K9C16_08155) 1709798..1710196 + 399 WP_057078255.1 phage tail terminator-like protein -
K9C16_RS08175 (K9C16_08160) 1710198..1710425 + 228 WP_057078256.1 hypothetical protein -
K9C16_RS08180 (K9C16_08165) 1710540..1710893 + 354 WP_057078257.1 hypothetical protein -
K9C16_RS08185 (K9C16_08170) 1710893..1712248 + 1356 WP_000002416.1 hypothetical protein -
K9C16_RS08190 (K9C16_08175) 1712301..1713218 + 918 WP_000094253.1 phage tail tube protein -
K9C16_RS08195 (K9C16_08180) 1713289..1713804 + 516 WP_024616020.1 hypothetical protein -
K9C16_RS08200 (K9C16_08185) 1714130..1714312 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
K9C16_RS08205 (K9C16_08190) 1714405..1714809 + 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K9C16_RS08210 (K9C16_08195) 1714908..1715588 + 681 WP_000721572.1 hypothetical protein -
K9C16_RS08215 (K9C16_08200) 1715590..1715853 + 264 WP_001275792.1 hypothetical protein -
K9C16_RS08220 (K9C16_08205) 1715981..1718626 + 2646 Protein_1597 tape measure protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - csuA/B / csuA / csuB / csuC / csuD / csuE / pgaB / pgaC / pgaD / plc 1430771..1835959 405188


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T215684 WP_000838146.1 NZ_CP082952:1714130-1714312 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T215684 NZ_CP110889:c438852-438388 [Thermoclostridium stercorarium]
TTGCTTTATGAATTTCTTCTCATCAAGGCCGACAACGAAGGTATAAATGTATATGAAAAGGAAATCGGGAAATTAAAAGG
ATTATACTTTGACGGAAATATAATAATTAATTCTTCAATCGAAACAAATTCTGAAAAAGCCTGTATTTTAGCCGAAGAAT
TGGGACATCATTATACGACCCATGGAAATATATTGAACCAATGTAAAGTAGAAAACAGAAAACAAGAGCGTAGAGCCCGC
GCCTGGGCATACGAACGACTGGTAAGTTTGAATAGCCTGATAGAGGCATCTAAACATGGTATCAGAAATAGATTTGAGTT
AGCTGAATTTTTGGGTGTATCCGAACGTTTTATTGATGAGGCAATTCAATATTACAAAGAAAAGTATGGTATTTGCCACA
AAGTTAGAGATTACATAGTTTATTTTGAACCTTTAGGAGTTCTAAAAAAAGTACAAAAGGAGTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT215684 WP_000966688.1 NZ_CP082952:1714405-1714809 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT215684 NZ_CP110889:c439215-438874 [Thermoclostridium stercorarium]
TTGGCTATTGGTGATAGAATAAAAAAACTAAGAATGGAAAAAGGCATGACGCAGGAAGAATTGGCTAAATATATTGATTC
CACCAAACAAACAATTTATAAATATGAAAATAATATTGTGACTAATATTCCCTCTGATAAGATTGAAAAAATTGCAGAGG
CATTAGGAACGACACCTTCTTATTTAATGGGCTGGAACGATACAGCTTCCAAAAATAATGTTAAAAAGCCCATCACTGTT
GCCGCACATATTCCTGATGGCGTTGAACTTACTGAGGAAGATATAAAACAAATCAATGACTTCATACAGTTCATTATTTC
AAAAAAGAAGGATCAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S3TWT7


Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References