Detailed information of TA system TA215683

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1273038..1273717
• Replicon: chromosome
• Accession: NZ_CP082952
• Organism: Acinetobacter baumannii strain Cl300

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: K9C16_RS06050
• Protein ID: WP_000838146.1
• Coordinates: 1273038..1273220 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: K9C16_RS06055
• Protein ID: WP_000966688.1
• Coordinates: 1273313..1273717 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K9C16_RS06010 (K9C16_06010)	1268068..1268475	+	408	WP_049592426.1	hypothetical protein	-
K9C16_RS06015 (K9C16_06015)	1268447..1268815	+	369	WP_057078082.1	hypothetical protein	-
K9C16_RS06020 (K9C16_06020)	1268817..1269215	+	399	WP_057078081.1	hypothetical protein	-
K9C16_RS06025 (K9C16_06025)	1269263..1269547	+	285	WP_057078080.1	hypothetical protein	-
K9C16_RS06030 (K9C16_06030)	1269629..1269979	+	351	WP_057078079.1	hypothetical protein	-
K9C16_RS06035 (K9C16_06035)	1269979..1271157	+	1179	WP_057078078.1	hypothetical protein	-
K9C16_RS06040 (K9C16_06040)	1271210..1272127	+	918	WP_057694252.1	phage tail tube protein	-
K9C16_RS06045 (K9C16_06045)	1272197..1272712	+	516	WP_001185585.1	hypothetical protein	-
K9C16_RS06050 (K9C16_06050)	1273038..1273220	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
K9C16_RS06055 (K9C16_06055)	1273313..1273717	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
K9C16_RS06060 (K9C16_06060)	1273817..1274341	+	525	WP_000721574.1	DUF4468 domain-containing protein	-
K9C16_RS06065 (K9C16_06065)	1274406..1274789	+	384	WP_000725052.1	hypothetical protein	-
K9C16_RS06070 (K9C16_06070)	1274851..1275597	+	747	WP_000599537.1	hypothetical protein	-
K9C16_RS06075 (K9C16_06075)	1275683..1276174	+	492	WP_000755583.1	DUF4468 domain-containing protein	-
K9C16_RS06080 (K9C16_06080)	1276217..1276483	-	267	WP_000774879.1	hypothetical protein	-
K9C16_RS06085 (K9C16_06085)	1276633..1277562	+	930	WP_057078076.1	ORF6N domain-containing protein	-
K9C16_RS06090 (K9C16_06090)	1277698..1278207	+	510	WP_057078075.1	Rha family transcriptional regulator	-
K9C16_RS06095 (K9C16_06095)	1278331..1278678	+	348	WP_057078074.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1240442..1291327	50885

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T215683 WP_000838146.1 NZ_CP082952:1273038-1273220 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T215683 NZ_CP110888:c2252125-2251775 [Thermoanaerobacter sp. RKWS2]
ATGGTGATAAAGAGAGGAGATATCTTTTATGCCGATTTAAGCCCTGTAATAGGCTCTGAACAGGGTGGAATTCGGCCTGT
ACTTATAATTCAAAATGATATTGGTAATAAATATAGTCCAACAGTAATAGTAGCGGCAATTACATCTCAGATCAACAAAG
CCAAATTGCCCACTCATGTTGAAATAAATGGGGCAGAATATGGACTTAACAAAGATTCTGTAGTATTGTTAGAACAAATC
AGAACTATTGACAAAAAACGTTTAAGAGAAAAAATTGGCCATTTTGACCAGGAAATGATGGAGAAAGTCAATGAAGCTTT
GCAAATAAGTTTAGGGTTGATTGATTTTTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT215683 WP_000966688.1 NZ_CP082952:1273313-1273717 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT215683 NZ_CP110888:c2252403-2252128 [Thermoanaerobacter sp. RKWS2]
GTGGGCGAAACAAAGCGAATACTTGTGAGCTTACCTCAGAGTTTATTAGAAGAGGTCGACGTTCTTGCCGCTATGGAAAA
CAGAAATCGCAGTGAATTTATAAGAGAAGCGATGAAATTATATATACGCGAGAGGAAAAAAGTTCAAATACGCGAGAGCA
TGAAAAAAGGATATCTCGAGATGGCAGCAATCAACAGTGAACTTGCGGAAATGGGCCTAACCGCAGAAAACGAATGTTTT
ACAGGATATGAAATGAAATTGAAAAAGTGTGATTGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6