Detailed information of TA system TA215678

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 977471..977966
• Replicon: chromosome
• Accession: NZ_CP082948
• Organism: Streptococcus suis strain SZ1908

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K8227_RS04785
• Protein ID: WP_211838269.1
• Coordinates: 977471..977737 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0Z8F611
• Locus tag: K8227_RS04790
• Protein ID: WP_024411326.1
• Coordinates: 977727..977966 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8227_RS04765 (K8227_04765)	973096..974166	+	1071	WP_012775101.1	tyrosine recombinase XerS	-
K8227_RS04770 (K8227_04770)	974236..975750	-	1515	WP_211838267.1	phosphomannomutase/phosphoglucomutase	-
K8227_RS04775 (K8227_04775)	975826..976767	-	942	WP_211838268.1	sensor histidine kinase	-
K8227_RS04780 (K8227_04780)	976764..977429	-	666	WP_024376604.1	response regulator transcription factor	-
K8227_RS04785 (K8227_04785)	977471..977737	-	267	WP_211838269.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K8227_RS04790 (K8227_04790)	977727..977966	-	240	WP_024411326.1	DUF6290 family protein	Antitoxin
K8227_RS04795 (K8227_04795)	978059..980029	-	1971	WP_211838270.1	FtsX-like permease family protein	-
K8227_RS04800 (K8227_04800)	980030..980782	-	753	WP_105120532.1	ABC transporter ATP-binding protein	-
K8227_RS04805 (K8227_04805)	980791..981180	-	390	WP_211838271.1	NisI/SpaI family lantibiotic immunity lipoprotein	-
K8227_RS04810 (K8227_04810)	981193..981333	-	141	WP_211838272.1	hypothetical protein	-
K8227_RS04815 (K8227_04815)	981473..982639	-	1167	WP_211838273.1	ATP-grasp domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-75)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10288.03 Da
• Isoelectric Point: 10.4518

>T215678 WP_211838269.1 NZ_CP082948:c977737-977471 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAVSLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Nucleotide

• Length: 267 bp

>T215678 NZ_CP110887:c3928368-3928189 [Dickeya solani]
ATGGACAGCAGGACGCTAATAGCAGAAATCAAGGCCGATGGATGGGAACTGGTAAGGGTTAACGGCAGTCATCACCATTT
TACCCACCCAACCAAACCGGGATTAGTGACCATCCCACACCCGAAGAAGGATTTACCGATAGGTACGGTAAAAAGCATCA
GGAAACAAGCGGGAATATGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8879.09 Da
• Isoelectric Point: 3.7832

>AT215678 WP_024411326.1 NZ_CP082948:c977966-977727 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAWAEYQEDLANGIEPITLEQMAEELGIEL

Nucleotide

• Length: 240 bp

>AT215678 NZ_CP110887:c3928161-3927751 [Dickeya solani]
ATGTTTTATCCCATTGCAATTGAAGCAGGCGACGATACTCATGCCTACGGCGTGACAGTGCCGGATCTGCCGGGCTGTTT
CTCCGCAGGTGATACGCTTGATGAGGCCATCGCCAATGCCAAAGACGCGATCACCGGCCATATCGAGCTGCTGATCGAGA
TGGGTCAGGATATTCCTGCTGTGTCATCAGTCGGAACGCTGGCGAAAGCACCGGAGTACACCGGTTACACCTGGGCTGTT
GTTGATATCGATGTCACCCGGCTGATGGGTGGGGCAGAGAAAATTAATGTCACGTTGCCGAAATCGCTGATTGACCGTAT
TGACCGTTGCGTAGCGAGTAACCCGGAATTTAAGAGCCGCTCAGGGTTCCTTGCTCAGGCAGCGTTAGAGCGGATTTCAT
CCATTCGCTAA

Structures

Antitoxin

• AlphaFold DB: A0A0Z8F611