Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 245660..246296 Replicon chromosome
Accession NZ_CP082944
Organism Metabacillus dongyingensis strain BY2G20

Toxin (Protein)


Gene name mazF Uniprot ID A0A2N5FBL1
Locus tag K8L98_RS01365 Protein ID WP_029286376.1
Coordinates 245946..246296 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A2N5FBR6
Locus tag K8L98_RS01360 Protein ID WP_029286378.1
Coordinates 245660..245941 (+) Length 94 a.a.

Genomic Context

K8L98_RS01345K8L98_RS01350K8L98_RS01355K8L98_RS01360K8L98_RS01365K8L98_RS01370K8L98_RS01375K8L98_RS01380K8L98_RS01385K8L98_RS01390K8L98_RS01395K8L98_RS01400K8L98_RS01405K8L98_RS01340
Location: 242386..242751 (366 bp)
Type: Others
Protein ID: WP_223439018.1
Location: 242897..243907 (1011 bp)
Type: Others
Protein ID: WP_223439019.1
Location: 244332..245513 (1182 bp)
Type: Others
Protein ID: WP_223439020.1
Location: 245660..245941 (282 bp)
Type: Antitoxin
Protein ID: WP_029286378.1
Location: 245946..246296 (351 bp)
Type: Toxin
Protein ID: WP_029286376.1
Location: 246434..247270 (837 bp)
Type: Others
Protein ID: WP_223439021.1
Location: 247267..247632 (366 bp)
Type: Others
Protein ID: WP_101569209.1
Location: 247635..248036 (402 bp)
Type: Others
Protein ID: WP_070878720.1
Location: 248048..249058 (1011 bp)
Type: Others
Protein ID: WP_223439022.1
Location: 249121..249453 (333 bp)
Type: Others
Protein ID: WP_223439023.1
Location: 249450..249932 (483 bp)
Type: Others
Protein ID: WP_223439024.1
Location: 249898..250686 (789 bp)
Type: Others
Protein ID: WP_070878724.1
Location: 250686..251285 (600 bp)
Type: Others
Protein ID: WP_223439025.1
Location: 241690..242283 (594 bp)
Type: Others
Protein ID: WP_223439017.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K8L98_RS01340 (K8L98_01340)241690..242283-594WP_223439017.1rhomboid family intramembrane serine protease-
K8L98_RS01345 (K8L98_01345)242386..242751+366WP_223439018.1holo-ACP synthase-
K8L98_RS01350 (K8L98_01350)242897..243907+1011WP_223439019.1outer membrane lipoprotein carrier protein LolA-
K8L98_RS01355 (K8L98_01355)244332..245513+1182WP_223439020.1alanine racemase-
K8L98_RS01360 (K8L98_01360)245660..245941+282WP_029286378.1YlcI/YnfO family proteinAntitoxin
K8L98_RS01365 (K8L98_01365)245946..246296+351WP_029286376.1type II toxin-antitoxin system endoribonuclease NdoAToxin
K8L98_RS01370 (K8L98_01370)246434..247270+837WP_223439021.1STAS domain-containing protein-
K8L98_RS01375 (K8L98_01375)247267..247632+366WP_101569209.1STAS domain-containing protein-
K8L98_RS01380 (K8L98_01380)247635..248036+402WP_070878720.1anti-sigma regulatory factor-
K8L98_RS01385 (K8L98_01385)248048..249058+1011WP_223439022.1PP2C family protein-serine/threonine phosphatase-
K8L98_RS01390 (K8L98_01390)249121..249453+333WP_223439023.1anti-sigma factor antagonist-
K8L98_RS01395 (K8L98_01395)249450..249932+483WP_223439024.1anti-sigma B factor RsbW-
K8L98_RS01400 (K8L98_01400)249898..250686+789WP_070878724.1RNA polymerase sigma factor SigB-
K8L98_RS01405 (K8L98_01405)250686..251285+600WP_223439025.1PP2C family serine/threonine-protein phosphatase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13036.06 Da        Isoelectric Point: 4.8781

>T215676 WP_029286376.1 NZ_CP082944:245946-246296 [Metabacillus dongyingensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDSKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T215676 NZ_CP110887:c3382924-3382721 [Dickeya solani]
ATGAAAAAAATCGACTATTTAATGCGTTTGCGTAAATGCACAACCATCGACACGCTTGAGCGTGTTATAGAAAAAAACAA
GTACGAGCTTTCCAACGATGAGCTTGAAATGTTCTATTCAGCTGCAGATCACCGCCTGGCAGAGCTGACGATGAATAAGC
TTTACGACAAAGTACCGACTGCTGTGTGGAGATACGTTCGCTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10572.01 Da        Isoelectric Point: 7.0156

>AT215676 WP_029286378.1 NZ_CP082944:245660-245941 [Metabacillus dongyingensis]
VSESSATTEILIRLPQALVSELDGLVKQENGNRSELIYQATKMYIRERKKRQIRESMRRGYMEMAKINLNIASEAFQAES
EADHTVERLVSGG

Download         Length: 282 bp

>AT215676 NZ_CP110887:c3383346-3382978 [Dickeya solani]
ATGGATGAGTACACACCCCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGACGAAAGTATCGC
GACATTAGGTGACAGCAGTCATGGCTGGGTGAATGATCCGACCTCTGCGGTCAACCTTCAACTAAACGAACTTATCGAGC
ATATTGCGGCATTTGTTGTTACCTACAAAATAAAATACCCGCATGAAGCGGCGCTATGTGAACGGGTTGAGAAATATCTG
GACGACACTTATATTCTTTTCAGCAATTACGGTATCAATGACACCGAGTTGCGGAAATGGCAAAAATCCAAGTCACAATT
ATTCAGAATGTTCTCAGAAAAGAGCATCTGTACGGTAGTAAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2N5FBL1

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2N5FBR6

References