Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 274368..275011 Replicon plasmid unnamed2
Accession NZ_CP082938
Organism Klebsiella pneumoniae strain NDM-71

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag K8M01_RS27840 Protein ID WP_094309882.1
Coordinates 274368..274784 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag K8M01_RS27845 Protein ID WP_049010641.1
Coordinates 274781..275011 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8M01_RS27820 (K8M01_27735) 270803..272056 + 1254 WP_102059795.1 lactose permease -
K8M01_RS27825 (K8M01_27740) 272171..273139 - 969 WP_200509628.1 IS5 family transposase -
K8M01_RS27830 273175..273387 + 213 Protein_289 hypothetical protein -
K8M01_RS27835 (K8M01_27745) 273593..274336 - 744 WP_230796877.1 hypothetical protein -
K8M01_RS27840 (K8M01_27750) 274368..274784 - 417 WP_094309882.1 type II toxin-antitoxin system VapC family toxin Toxin
K8M01_RS27845 (K8M01_27755) 274781..275011 - 231 WP_049010641.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K8M01_RS27850 (K8M01_27760) 275317..275910 + 594 WP_004144479.1 hypothetical protein -
K8M01_RS27855 (K8M01_27765) 275929..276369 + 441 WP_230796875.1 hypothetical protein -
K8M01_RS27860 (K8M01_27770) 276615..279236 - 2622 WP_230796873.1 histidinol-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..299755 299755
- flank IS/Tn - - 272171..273139 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-128)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.53 Da        Isoelectric Point: 7.8874

>T215675 WP_094309882.1 NZ_CP082938:c274784-274368 [Klebsiella pneumoniae]
VNKIYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCARVDAILPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVLGLNLEDWVK

Download         Length: 417 bp

>T215675 NZ_CP110887:2894719-2895150 [Dickeya solani]
GTGGCCCAGTGGCAATGTGATTTACGCGTATCCTGGCGCATGCAGTTGTTTTCGCTGCTGACGCACGGGTTTCTGGTGCT
GATGATCCTGCTGGCGCCCTGGCCGGACGGCTATGCGCCGCTGTGGCTGGGGTTGGTGACGCTGGTGGTGTTCGGTTTCG
TGCGCAGTCAGCGCATCATTAAGTCGCGTCAGGGGGAAATTTCCCTGCATGGGGAAAACCAACTGCACTGGCAGCAGCGT
GACTGGCAGATAGCCCGGCGACCGTGGGTGATGCGCAACGGCGTGTTGCTGTCGTTGCGGGCGACGACTGGCAAAGGGCA
TCAGCGTCTGTGGCTGGCGTCAGACAGTATGGGCAATGAAGAGTGGCGGCTGTTGCGCCAGCTGTTGCAGCAGCACCCGC
TGCAGGGAACGGAATCTTCCCGCCATCATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8681.76 Da        Isoelectric Point: 4.4692

>AT215675 WP_049010641.1 NZ_CP082938:c275011-274781 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFASLEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT215675 NZ_CP110887:2894472-2894738 [Dickeya solani]
ATGGACATCAATAACAAATCACGTATTCACTGGGCGTGCAGACGCGGAATGCGTGAACTGGATATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTGAGCGACGACGACAAGCAGCATTTCATCCGTCTGTTGCAGTGCGACGATCCCGACT
TGTTCAACTGGCTGATGAACCATGGCGAGCCGGTGGATCCGGAGCTGAAACGTATGGTTTCCCTTATTCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCAATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References