Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4789677..4790334 Replicon chromosome
Accession NZ_CP082936
Organism Klebsiella pneumoniae strain NDM-71

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K8M01_RS23305 Protein ID WP_002916310.1
Coordinates 4789924..4790334 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K8M01_RS23300 Protein ID WP_002916312.1
Coordinates 4789677..4789943 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8M01_RS23275 (4784833) 4784833..4786266 - 1434 WP_004174453.1 6-phospho-beta-glucosidase -
K8M01_RS23280 (4786385) 4786385..4787113 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K8M01_RS23285 (4787163) 4787163..4787474 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
K8M01_RS23290 (4787638) 4787638..4788297 + 660 WP_004174454.1 hemolysin III family protein -
K8M01_RS23295 (4788448) 4788448..4789431 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
K8M01_RS23300 (4789677) 4789677..4789943 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K8M01_RS23305 (4789924) 4789924..4790334 + 411 WP_002916310.1 protein YgfX Toxin
K8M01_RS23310 (4790341) 4790341..4790862 - 522 WP_002916308.1 flavodoxin FldB -
K8M01_RS23315 (4790963) 4790963..4791859 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K8M01_RS23320 (4791882) 4791882..4792595 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K8M01_RS23325 (4792601) 4792601..4794334 + 1734 WP_046623736.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T215671 WP_002916310.1 NZ_CP082936:4789924-4790334 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T215671 NZ_CP110886:c4877512-4877135 [Dickeya solani]
ATGAAATGGGTGAGTGCGCAGGACGTCATTGACTTCCATGATCGTATTTTGCAGGTGTTGCCTGGTGTGGTGGGTATGGC
TGATCCGGGTCGGGCTGAGGAGTTGATTTATCGAGTACAAAACCGTCTTTATTATGAAGGTGTGACCGAACTGTTTGAGT
TGGCGGCGACGTATTGGGTAACTATTGCTCGTGGTCATATTTTTAATGATGGCAATAAACGCACTGCTTTTTTTGTTACC
ATGACATTTTTGCGCCGCAATGGCATATTGATTGTCGATAACGATAATTCGCTGGAAGAACTCACCATTAAGGCGGCAAC
CGGAGAATGCCTGGTGTCGGAACTCGCCGAACAATTAAGACAACGGGTGGAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT215671 WP_002916312.1 NZ_CP082936:4789677-4789943 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT215671 NZ_CP110886:c4877730-4877509 [Dickeya solani]
ATGAAGACTTATACCATTACTGAAGCCCGGCAAAATATTGCGACAGTCATTGATACGGCGGCCAGCGGTGAGCCGGTAGA
GATTAAGCGTCGGGATGGCACCTCGGCTGTACTCATCCCCAAAGCAGAGTTTGAGGCTTATCAGAAAGCCAGATTAGACG
CTGAATTCGATTTCATCATGCAGCGCCACGGACACACAATCAAAGCGCTCGCCGACAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References