Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3440421..3440937 Replicon chromosome
Accession NZ_CP082936
Organism Klebsiella pneumoniae strain NDM-71

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag K8M01_RS16730 Protein ID WP_002886902.1
Coordinates 3440421..3440705 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K8M01_RS16735 Protein ID WP_002886901.1
Coordinates 3440695..3440937 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8M01_RS16705 (3435905) 3435905..3436213 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
K8M01_RS16710 (3436298) 3436298..3436471 + 174 WP_002886906.1 hypothetical protein -
K8M01_RS16715 (3436474) 3436474..3437217 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K8M01_RS16720 (3437574) 3437574..3439712 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
K8M01_RS16725 (3439953) 3439953..3440417 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K8M01_RS16730 (3440421) 3440421..3440705 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K8M01_RS16735 (3440695) 3440695..3440937 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K8M01_RS16740 (3441015) 3441015..3442925 - 1911 WP_004152270.1 PRD domain-containing protein -
K8M01_RS16745 (3442948) 3442948..3444102 - 1155 WP_065800339.1 lactonase family protein -
K8M01_RS16750 (3444168) 3444168..3444908 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T215667 WP_002886902.1 NZ_CP082936:c3440705-3440421 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T215667 NZ_CP110886:c3928423-3928244 [Dickeya solani]
ATGGACAGCAGGACGCTAATAGCAGAAATCAAGGCCGATGGATGGGAACTGGTAAGGGTTAACGGCAGTCATCACCATTT
TACCCACCCAACCAAACCGGGATTAGTGACCATCCCACACCCGAAGAAGGATTTACCGATAGGTACGGTAAAAAGCATCA
GGAAACAAGCGGGAATATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT215667 WP_002886901.1 NZ_CP082936:c3440937-3440695 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT215667 NZ_CP110886:c3928216-3927806 [Dickeya solani]
ATGTTTTATCCCATTGCAATTGAAGCAGGCGACGATACTCATGCCTACGGCGTGACAGTGCCGGATCTGCCGGGCTGTTT
CTCCGCAGGTGATACGCTTGATGAGGCCATCGCCAATGCCAAAGACGCGATCACCGGCCATATCGAGCTGCTGATCGAGA
TGGGTCAGGATATTCCTGCTGTGTCATCAGTCGGAACGCTGGCGAAAGCACCGGAGTACACCGGTTACACCTGGGCTGTT
GTTGATATCGATGTCACCCGGCTGATGGGTGGGGCAGAGAAAATTAATGTCACGTTGCCGAAATCGCTGATTGACCGTAT
TGACCGTTGCGTAGCGAGTAACCCGGAATTTAAGAGCCGCTCAGGGTTCCTTGCTCAGGCAGCGTTAGAGCGGATTTCAT
CCATTCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References