Detailed information of TA system TA215664

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1409249..1410837
• Replicon: chromosome
• Accession: NZ_CP082936
• Organism: Klebsiella pneumoniae strain NDM-71

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A6T928
• Locus tag: K8M01_RS06845
• Protein ID: WP_004176197.1
• Coordinates: 1409249..1410571 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: K8M01_RS06850
• Protein ID: WP_004176198.1
• Coordinates: 1410571..1410837 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8M01_RS06830 (1404305)	1404305..1406806	+	2502	WP_016831617.1	fimbria/pilus outer membrane usher protein	-
K8M01_RS06835 (1406794)	1406794..1407798	+	1005	WP_004176196.1	fimbrial protein	-
K8M01_RS06840 (1407940)	1407940..1409232	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
K8M01_RS06845 (1409249)	1409249..1410571	-	1323	WP_004176197.1	type II toxin-antitoxin system HipA family toxin	Toxin
K8M01_RS06850 (1410571)	1410571..1410837	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
K8M01_RS06855 (1411103)	1411103..1411429	-	327	WP_004176200.1	hydroxyisourate hydrolase	-
K8M01_RS06860 (1411426)	1411426..1411926	-	501	WP_004176202.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
K8M01_RS06865 (1411904)	1411904..1413283	-	1380	WP_004176204.1	nucleobase:cation symporter-2 family protein	-
K8M01_RS06870 (1413629)	1413629..1414783	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
K8M01_RS06875 (1414764)	1414764..1415687	-	924	WP_004176206.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49111.41 Da
• Isoelectric Point: 7.5357

>T215664 WP_004176197.1 NZ_CP082936:c1410571-1409249 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T215664 NZ_CP110886:2894774-2895205 [Dickeya solani]
GTGGCCCAGTGGCAATGTGATTTACGCGTATCCTGGCGCATGCAGTTGTTTTCGCTGCTGACGCACGGGTTTCTGGTGCT
GATGATCCTGCTGGCGCCCTGGCCGGACGGCTATGCGCCGCTGTGGCTGGGGTTGGTGACGCTGGTGGTGTTCGGTTTCG
TGCGCAGTCAGCGCATCATTAAGTCGCGTCAGGGGGAAATTTCCCTGCATGGGGAAAACCAACTGCACTGGCAGCAGCGT
GACTGGCAGATAGCCCGGCGACCGTGGGTGATGCGCAACGGCGTGTTGCTGTCGTTGCGGGCGACGACTGGCAAAGGGCA
TCAGCGTCTGTGGCTGGCGTCAGACAGTATGGGCAATGAAGAGTGGCGGCTGTTGCGCCAGCTGTTGCAGCAGCACCCGC
TGCAGGGAACGGAATCTTCCCGCCATCATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT215664 WP_004176198.1 NZ_CP082936:c1410837-1410571 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT215664 NZ_CP110886:2894527-2894793 [Dickeya solani]
ATGGACATCAATAACAAATCACGTATTCACTGGGCGTGCAGACGCGGAATGCGTGAACTGGATATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTGAGCGACGACGACAAGCAGCATTTCATCCGTCTGTTGCAGTGCGACGATCCCGACT
TGTTCAACTGGCTGATGAACCATGGCGAGCCGGTGGATCCGGAGCTGAAACGTATGGTTTCCCTTATTCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCAATGTGA

Structures

Toxin

• AlphaFold DB: A6T928