Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 155089..155614 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP082930 | ||
| Organism | Salmonella enterica subsp. enterica serovar London isolate N18-04674 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | A0A5J1SSZ4 |
| Locus tag | K6991_RS23350 | Protein ID | WP_001159865.1 |
| Coordinates | 155309..155614 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | I3VZQ6 |
| Locus tag | K6991_RS23345 | Protein ID | WP_000813642.1 |
| Coordinates | 155089..155307 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6991_RS23320 (150660) | 150660..150899 | - | 240 | Protein_170 | hypothetical protein | - |
| K6991_RS23325 (151278) | 151278..153158 | + | 1881 | WP_263258470.1 | KUP/HAK/KT family potassium transporter | - |
| K6991_RS23330 (153230) | 153230..153442 | + | 213 | Protein_172 | hypothetical protein | - |
| K6991_RS23335 (153701) | 153701..154117 | - | 417 | WP_001674757.1 | type II toxin-antitoxin system VapC family toxin | - |
| K6991_RS23340 (154114) | 154114..154344 | - | 231 | WP_001261285.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| K6991_RS23345 (155089) | 155089..155307 | + | 219 | WP_000813642.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| K6991_RS23350 (155309) | 155309..155614 | + | 306 | WP_001159865.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| K6991_RS23355 (155616) | 155616..155906 | + | 291 | WP_001266174.1 | hypothetical protein | - |
| K6991_RS23360 (155903) | 155903..156364 | + | 462 | Protein_178 | 3'-5' exonuclease | - |
| K6991_RS23365 (156593) | 156593..157051 | + | 459 | Protein_179 | 3'-5' exonuclease | - |
| K6991_RS23370 (157086) | 157086..157868 | + | 783 | WP_000082173.1 | site-specific integrase | - |
| K6991_RS23375 (158019) | 158019..158960 | - | 942 | WP_000412547.1 | Rpn family recombination-promoting nuclease/putative transposase | - |
| K6991_RS23380 (159493) | 159493..159771 | + | 279 | WP_001209539.1 | hypothetical protein | - |
| K6991_RS23385 (159768) | 159768..160190 | + | 423 | WP_000691102.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | faeC / faeD / faeE / faeF / faeH / faeI / faeJ / faeJ | 1..165260 | 165260 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11577.33 Da Isoelectric Point: 5.6919
>T215655 WP_001159865.1 NZ_CP082930:155309-155614 [Salmonella enterica subsp. enterica serovar London]
MQFKVYTYKKESRYTLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRLMTTDMASVPASVIGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYTYKKESRYTLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRLMTTDMASVPASVIGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T215655 NZ_CP110873:c3878063-3877740 [Enterobacter kobei]
ATGAAATCTCAACCTGCAACAACTCAGCGGGCGGCGAAGCCCTGCCTGTCACCCGTGGATGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTCACCCTCAACGACACACCATTCAGTGAGGAACGTGTTATACAGGAACATATCG
ATGCCGGTATCACGCTGGCTGATGCCATTAACTTTCTAGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGAGGGTTT
AGCTGGCAAGAACAAACGCCATATCTCACGATTATTGATATCATGAGGGCCCGCCTGGATCTGGGTTTATTAAATCGTAA
TTAG
ATGAAATCTCAACCTGCAACAACTCAGCGGGCGGCGAAGCCCTGCCTGTCACCCGTGGATGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTCACCCTCAACGACACACCATTCAGTGAGGAACGTGTTATACAGGAACATATCG
ATGCCGGTATCACGCTGGCTGATGCCATTAACTTTCTAGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGAGGGTTT
AGCTGGCAAGAACAAACGCCATATCTCACGATTATTGATATCATGAGGGCCCGCCTGGATCTGGGTTTATTAAATCGTAA
TTAG
Antitoxin
Download Length: 73 a.a. Molecular weight: 8328.19 Da Isoelectric Point: 4.5358
>AT215655 WP_000813642.1 NZ_CP082930:155089-155307 [Salmonella enterica subsp. enterica serovar London]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADENRNW
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADENRNW
Download Length: 219 bp
>AT215655 NZ_CP110873:c3878401-3878084 [Enterobacter kobei]
ATGAGCAACATCACATGGGGCCTGCAGCGGGATATCACGCCACGCCTGGGAGCCCGTCTGGTACAGGAGGGGAACCGGTT
GCATTATTTAGCTGACCGGGCCAGCATCACCGGCCAGTTCAGTGACGCAGAATGCCGGAAGCTGGATGTGGCATTTCCGT
ACTTTATCCGCCAGATGGAATCCATGCTGACTACCGGTGAACTGAATCCTCGCCACACCCACTGCGTCACTCTGTACCGC
AACGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATATATCGCCATTTATCCCACTCAGCGCTAA
ATGAGCAACATCACATGGGGCCTGCAGCGGGATATCACGCCACGCCTGGGAGCCCGTCTGGTACAGGAGGGGAACCGGTT
GCATTATTTAGCTGACCGGGCCAGCATCACCGGCCAGTTCAGTGACGCAGAATGCCGGAAGCTGGATGTGGCATTTCCGT
ACTTTATCCGCCAGATGGAATCCATGCTGACTACCGGTGAACTGAATCCTCGCCACACCCACTGCGTCACTCTGTACCGC
AACGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATATATCGCCATTTATCCCACTCAGCGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5J1SSZ4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A600YYQ0 |