Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 153701..154344 Replicon plasmid unnamed1
Accession NZ_CP082930
Organism Salmonella enterica subsp. enterica serovar London isolate N18-04674

Toxin (Protein)


Gene name vagD Uniprot ID A0A5I3EPT5
Locus tag K6991_RS23335 Protein ID WP_001674757.1
Coordinates 153701..154117 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A5I3ERT2
Locus tag K6991_RS23340 Protein ID WP_001261285.1
Coordinates 154114..154344 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6991_RS23315 (149167) 149167..150156 + 990 WP_000608197.1 AraC family transcriptional regulator -
K6991_RS23320 (150660) 150660..150899 - 240 Protein_170 hypothetical protein -
K6991_RS23325 (151278) 151278..153158 + 1881 WP_263258470.1 KUP/HAK/KT family potassium transporter -
K6991_RS23330 (153230) 153230..153442 + 213 Protein_172 hypothetical protein -
K6991_RS23335 (153701) 153701..154117 - 417 WP_001674757.1 type II toxin-antitoxin system VapC family toxin Toxin
K6991_RS23340 (154114) 154114..154344 - 231 WP_001261285.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K6991_RS23345 (155089) 155089..155307 + 219 WP_000813642.1 type II toxin-antitoxin system antitoxin CcdA -
K6991_RS23350 (155309) 155309..155614 + 306 WP_001159865.1 type II toxin-antitoxin system toxin CcdB -
K6991_RS23355 (155616) 155616..155906 + 291 WP_001266174.1 hypothetical protein -
K6991_RS23360 (155903) 155903..156364 + 462 Protein_178 3'-5' exonuclease -
K6991_RS23365 (156593) 156593..157051 + 459 Protein_179 3'-5' exonuclease -
K6991_RS23370 (157086) 157086..157868 + 783 WP_000082173.1 site-specific integrase -
K6991_RS23375 (158019) 158019..158960 - 942 WP_000412547.1 Rpn family recombination-promoting nuclease/putative transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - faeC / faeD / faeE / faeF / faeH / faeI / faeJ / faeJ 1..165260 165260


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.65 Da        Isoelectric Point: 8.5291

>T215654 WP_001674757.1 NZ_CP082930:c154117-153701 [Salmonella enterica subsp. enterica serovar London]
VKKMYMPDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCARLDAVLPWDRA
AVDATMEIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFERVPGLVLEDWAR

Download         Length: 417 bp

>T215654 NZ_CP110873:c2814178-2814075 [Enterobacter kobei]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8779.91 Da        Isoelectric Point: 4.3775

>AT215654 WP_001261285.1 NZ_CP082930:c154344-154114 [Salmonella enterica subsp. enterica serovar London]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMAEREDVVTDEGRFNL

Download         Length: 231 bp

>AT215654 NZ_CP110873:2814068-2814213 [Enterobacter kobei]
AATAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I3EPT5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I3ERT2

References