Detailed information of TA system TA215653

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 60838..61463
• Replicon: plasmid unnamed1
• Accession: NZ_CP082930
• Organism: Salmonella enterica subsp. enterica serovar London isolate N18-04674

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: K6991_RS22855
• Protein ID: WP_000911322.1
• Coordinates: 60838..61236 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8F2UQ48
• Locus tag: K6991_RS22860
• Protein ID: WP_000450263.1
• Coordinates: 61236..61463 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6991_RS22840 (56831)	56831..57313	+	483	WP_000787664.1	hypothetical protein	-
K6991_RS22845 (57559)	57559..58290	+	732	WP_044127382.1	conjugal transfer complement resistance protein TraT	-
K6991_RS22850 (58667)	58667..60829	+	2163	WP_263258477.1	type IV conjugative transfer system coupling protein TraD	-
K6991_RS22855 (60838)	60838..61236	-	399	WP_000911322.1	type II toxin-antitoxin system VapC family toxin	Toxin
K6991_RS22860 (61236)	61236..61463	-	228	WP_000450263.1	toxin-antitoxin system antitoxin VapB	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	faeC / faeD / faeE / faeF / faeH / faeI / faeJ / faeJ	1..165260	165260

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14887.13 Da
• Isoelectric Point: 8.5264

>T215653 WP_000911322.1 NZ_CP082930:c61236-60838 [Salmonella enterica subsp. enterica serovar London]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLDVLDYDTPAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVGGLRTEDWS

Nucleotide

• Length: 399 bp

>T215653 NZ_CP110873:1739866-1740390 [Enterobacter kobei]
ATCGTGGCAAATCTCACGATCGAAATGTTTTCAGAGGGAAGTGATTACGATTTCAGGGGCTTCGATTGTGGTGAACCCTC
GCTAAATGCCTTCCTGACGGAACATCTGGTGCGTCAGCACAAGGGACGGATATTGCGAGGTTACCTGCTTAAAGATCGTG
ACCATCCGCGTGTGCTGGGCTATTACACGTTGTCCGGAAGCTGCTTTGAAAAAGCGATGCTTCCTTCTAAGACCCAGCAG
CGTCGGATCCCCTATGTCAACGTACCCAGTGTGACGCTGGGGCGTCTGGCTGTGCATAAAGATCTACAGGGAAAGGAGTG
GGGAACAACGCTCGTCGCACATGCTATGCGCGTTGTGTATCTGGCATCGCAGGCGGTAGGGGTACACGGAATCTTTGTTG
ATGCTCTCAATGAACAGGCAAAACGATTCTATCTGAAGCAGGGTTTTATTCCGCTGACAGGTGAAAACAGCCATTCTCTT
TTCTTCCCCACAAAATCTATCGAACAACTCTTTGAGCAGGCGTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8532.53 Da
• Isoelectric Point: 4.7513

>AT215653 WP_000450263.1 NZ_CP082930:c61463-61236 [Salmonella enterica subsp. enterica serovar London]
METSVFLSNRSQAVRLPKAVALPEHVKRVEVIAVGRTRIITPAGESWDEWFDGNNVSADFMDNREQPSVQERESF

Nucleotide

• Length: 228 bp

>AT215653 NZ_CP110873:1739593-1739862 [Enterobacter kobei]
ATGCCAGCACTTAAAAAACAGCGTATCGATCTTCGCTTAACGGACGAAGACAAAACAATGATTGAAGAAGCGGCGGCGAT
GACGAACCAGACAATCACCCAGTTTATGGTGAACAGTGCGTCAGAACGCGCTGCTGAAGTCATCGAACAACATCGGCGTC
TCGTATTAAACGAGTCATCATGGAATGCGGTGATGGACGCCATCGACAATCCGCCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCAAAACGTCTTCGAAACATGGAGTGA