Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
| Location | 19382..19941 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP082930 | ||
| Organism | Salmonella enterica subsp. enterica serovar London isolate N18-04674 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A5J1T663 |
| Locus tag | K6991_RS22575 | Protein ID | WP_000421254.1 |
| Coordinates | 19666..19941 (+) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A5I3EQ05 |
| Locus tag | K6991_RS22570 | Protein ID | WP_001674495.1 |
| Coordinates | 19382..19666 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6991_RS22545 (15310) | 15310..15572 | - | 263 | Protein_15 | ATP-binding protein | - |
| K6991_RS22550 (15596) | 15596..15742 | + | 147 | Protein_16 | transposase | - |
| K6991_RS22555 (15745) | 15745..15879 | + | 135 | Protein_17 | DUF1281 domain-containing protein | - |
| K6991_RS22560 (16034) | 16034..18013 | + | 1980 | WP_263258473.1 | NEL-type E3 ubiquitin ligase domain-containing protein | - |
| K6991_RS22565 (18113) | 18113..18745 | + | 633 | Protein_19 | IS256 family transposase | - |
| K6991_RS22570 (19382) | 19382..19666 | + | 285 | WP_001674495.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| K6991_RS22575 (19666) | 19666..19941 | + | 276 | WP_000421254.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K6991_RS22580 (20048) | 20048..20320 | + | 273 | WP_001105070.1 | hypothetical protein | - |
| K6991_RS22585 (20531) | 20531..20926 | - | 396 | WP_000445934.1 | plasmid partitioning/stability family protein | - |
| K6991_RS22590 (20926) | 20926..21885 | - | 960 | WP_000921955.1 | plasmid segregation protein ParM | - |
| K6991_RS22595 (22327) | 22327..23229 | + | 903 | WP_198430388.1 | DUF1281 domain-containing protein | - |
| K6991_RS22600 (23226) | 23226..23537 | + | 312 | WP_198430387.1 | hypothetical protein | - |
| K6991_RS22605 (23614) | 23614..24297 | + | 684 | WP_000086176.1 | DNA methylase | - |
| K6991_RS22610 (24298) | 24298..24519 | + | 222 | WP_001104897.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | faeC / faeD / faeE / faeF / faeH / faeI / faeJ / faeJ | 1..165260 | 165260 | |
| - | flank | IS/Tn | - | - | 18113..18781 | 668 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10731.41 Da Isoelectric Point: 9.9324
>T215652 WP_000421254.1 NZ_CP082930:19666-19941 [Salmonella enterica subsp. enterica serovar London]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRIGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRIGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR
Download Length: 276 bp
>T215652 NZ_CP110873:c1194365-1194003 [Enterobacter kobei]
ATGTGGAATGTCGAGACAACGGACAGATTTGATCAATGGTACTTCGAACAAACAACAGCATTAAAAGAAGATGTGCTAGC
GATGATGCATATTCTTGCTGAGTTTGGCCCAACGCTTGGGCGGCCATACGTAGATACCGTGAAGGCTTCAGCCTATGCGA
ACATGAAGGAATTACGGATTCAACATGCGGGAAATCCCATCAGAGCTTTTTTTGCTTTTGATCCTGACCGTAAGGCAATT
GTGCTCTGTGCTGGAAACAAAACCGGTTGCAATCAAAAACGGTTTTATAACGAAATGATTACGCTGGCTGACGTTGAGTA
CAGCAGACATCTGGCGGATAAGGAGGCCATATGGCAACGCTAA
ATGTGGAATGTCGAGACAACGGACAGATTTGATCAATGGTACTTCGAACAAACAACAGCATTAAAAGAAGATGTGCTAGC
GATGATGCATATTCTTGCTGAGTTTGGCCCAACGCTTGGGCGGCCATACGTAGATACCGTGAAGGCTTCAGCCTATGCGA
ACATGAAGGAATTACGGATTCAACATGCGGGAAATCCCATCAGAGCTTTTTTTGCTTTTGATCCTGACCGTAAGGCAATT
GTGCTCTGTGCTGGAAACAAAACCGGTTGCAATCAAAAACGGTTTTATAACGAAATGATTACGCTGGCTGACGTTGAGTA
CAGCAGACATCTGGCGGATAAGGAGGCCATATGGCAACGCTAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10460.87 Da Isoelectric Point: 5.6558
>AT215652 WP_001674495.1 NZ_CP082930:19382-19666 [Salmonella enterica subsp. enterica serovar London]
MQMKNNSAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR
MQMKNNSAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR
Download Length: 285 bp
>AT215652 NZ_CP110873:c1194015-1193716 [Enterobacter kobei]
ATGGCAACGCTAAAAGAACTCATGGCACAACAGAGCGCGGAAAGTCAGGAGCGTATTGCGGCTAAAGTTGATGTAATACG
CAGAATTGTTGCCCTGAACCAACTGCGGGAAGAGCTCAATATTTCGCAGACAGAACTGGCCGCGGCAATGGGGGTAAAAC
AACCAACTGTGGCAAAAATCGAACAGCCGGGAAACGATCCCCGGCTTTCAACACTCAAACGCTATGTCAGTGCGCTCGGC
GGTGAAATGAGCATTGATGTGACGTTACCGAATGGGAAACGAATAGCGTTTCAGATTTGA
ATGGCAACGCTAAAAGAACTCATGGCACAACAGAGCGCGGAAAGTCAGGAGCGTATTGCGGCTAAAGTTGATGTAATACG
CAGAATTGTTGCCCTGAACCAACTGCGGGAAGAGCTCAATATTTCGCAGACAGAACTGGCCGCGGCAATGGGGGTAAAAC
AACCAACTGTGGCAAAAATCGAACAGCCGGGAAACGATCCCCGGCTTTCAACACTCAAACGCTATGTCAGTGCGCTCGGC
GGTGAAATGAGCATTGATGTGACGTTACCGAATGGGAAACGAATAGCGTTTCAGATTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5J1T663 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5I3EQ05 |