Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4169417..4170198 Replicon chromosome
Accession NZ_CP082929
Organism Salmonella enterica subsp. enterica serovar London isolate N18-04674

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A5I1HVL4
Locus tag K6991_RS20195 Protein ID WP_023255089.1
Coordinates 4169417..4169908 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag K6991_RS20200 Protein ID WP_001271379.1
Coordinates 4169905..4170198 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6991_RS20170 (4166298) 4166298..4167128 - 831 WP_023221225.1 fimbria/pilus periplasmic chaperone -
K6991_RS20175 (4167330) 4167330..4167542 - 213 WP_001293880.1 PapB/FocB family fimbrial expression transcriptional regulator -
K6991_RS20180 (4168167) 4168167..4168310 + 144 Protein_3947 transposase -
K6991_RS20185 (4168327) 4168327..4168673 + 347 Protein_3948 Rpn family recombination-promoting nuclease/putative transposase -
K6991_RS20190 (4168954) 4168954..4169202 - 249 Protein_3949 IS481 family transposase -
K6991_RS20195 (4169417) 4169417..4169908 - 492 WP_023255089.1 GNAT family N-acetyltransferase Toxin
K6991_RS20200 (4169905) 4169905..4170198 - 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
K6991_RS20205 (4170516) 4170516..4170738 + 223 Protein_3952 hypothetical protein -
K6991_RS20210 (4171004) 4171004..4171879 + 876 WP_000921674.1 AraC family transcriptional regulator -
K6991_RS20215 (4171876) 4171876..4172163 + 288 WP_001269916.1 transcriptional regulator RtsB -
K6991_RS20220 (4172186) 4172186..4172400 + 215 Protein_3955 hypothetical protein -
K6991_RS20225 (4172408) 4172408..4172551 + 144 Protein_3956 hypothetical protein -
K6991_RS20230 (4172663) 4172663..4172752 + 90 Protein_3957 hypothetical protein -
K6991_RS20235 (4173041) 4173041..4173946 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4158810..4173901 15091


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17633.45 Da        Isoelectric Point: 7.7297

>T215649 WP_023255089.1 NZ_CP082929:c4169908-4169417 [Salmonella enterica subsp. enterica serovar London]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T215649 NZ_CP110873:490335-490685 [Enterobacter kobei]
ATGGTGAAGCGACCTTGTTTTGAACGAGGTGATATCGTTCTCGTCGGCTTCGATCCTGCAAATGGTCATGAACAAAAGGG
CGCAGGCAGGCCCGCTTTAGTGCTATCCGTTAGCGCGTTCAACCAGCTGGGAATGACGCTGGTTGCGCCTGTTACACAGG
GGGGAAATTTTGCCCGCTATGCGGGTTTCAGTGTGCCGCTGTCTTGTGAAGAAGGGAATATTCAGGGCGTCATTCTGGTA
AACCAAATCCGAATGATGGATTTGGGCGCGCGTCTGGCAAAACGAATAGGCGTGGCATCAGATGAAACCGTAGAAGATGC
GCTTTTAAGGCTACAGGCCATCCTGAGTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT215649 WP_001271379.1 NZ_CP082929:c4170198-4169905 [Salmonella enterica subsp. enterica serovar London]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT215649 NZ_CP110873:490090-490341 [Enterobacter kobei]
ATGCGTATAACCATTAAGAAATGGGGAAACAGTGCCGGTATGGTCATTCCTGGCGTAGTAATGAAAGAACTTGGCCTAAA
ACCAGGTCAGAGTATGGAGGCTCAGGTGACAAATAATCAGTTAGTGCTCACACCGGTGAGTAAACAGTACTCGCTTGAAG
AGTTGTTGGCGCAGTGTGATATGTCAGCCCCGGAAATTAACGAACAAGACGTATGGGGTACGTCAGGTCCCGTAGGTGAC
GAAGTATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I1HVL4

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References