Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4054836..4055352 Replicon chromosome
Accession NZ_CP082929
Organism Salmonella enterica subsp. enterica serovar London isolate N18-04674

Toxin (Protein)


Gene name relE Uniprot ID A0A5I6CHB9
Locus tag K6991_RS19565 Protein ID WP_000220581.1
Coordinates 4054836..4055120 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag K6991_RS19570 Protein ID WP_000212724.1
Coordinates 4055110..4055352 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6991_RS19550 (4050048) 4050048..4051700 + 1653 WP_023257400.1 alpha,alpha-phosphotrehalase -
K6991_RS19555 (4052109) 4052109..4054247 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
K6991_RS19560 (4054368) 4054368..4054832 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K6991_RS19565 (4054836) 4054836..4055120 - 285 WP_000220581.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6991_RS19570 (4055110) 4055110..4055352 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6991_RS19575 (4055430) 4055430..4057343 - 1914 WP_001212148.1 BglG family transcription antiterminator -
K6991_RS19580 (4057360) 4057360..4058100 - 741 WP_023229489.1 KDGP aldolase family protein -
K6991_RS19585 (4058097) 4058097..4059215 - 1119 WP_023256352.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
K6991_RS19590 (4059199) 4059199..4060332 - 1134 WP_023257225.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10868.70 Da        Isoelectric Point: 10.0482

>T215648 WP_000220581.1 NZ_CP082929:c4055120-4054836 [Salmonella enterica subsp. enterica serovar London]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T215648 NZ_CP110873:31790-32029 [Enterobacter kobei]
CTGGGGCGAACCATAGAAAAGAGCCATTGCCCGACGCCTGTTGCGCTAAGAAAAATCTTTCCAACGCTAGATAATTTGAA
GTATCTCGATAAGCATTATGTTATTGATATTGCTAACAACAACCTCAGAATAGTGGCTCTCATATTCTTTGAAAGCCAAA
AGTTTTATGTGCGCCATGTTTTTACTAATAAGGAATATGACCGTTTTACGGAGAAACATCGCACTAAGGGGAAGAAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT215648 WP_000212724.1 NZ_CP082929:c4055352-4055110 [Salmonella enterica subsp. enterica serovar London]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT215648 NZ_CP110873:32026-32445 [Enterobacter kobei]
ATGATGATCGTAGCTGATGCAATGAAAGCAACGCATGCCCTTGTCGCGGCGGTTCCTTTATTGGGTGAACATCCAAACGA
GAAAGATTACCAGGACGCACTTGAGCTGGTTGAGTATTTACTGATGAACGAACCTGGCAGCCCTTTGCTGGATATCGTAT
GTGCAAGAATTCGTCGTTACGAAGCCAATCGGCCCGAAATTGTCGCCTTACGCCAGGAGATGGAATCTGTCCCAGTGGGC
ATTGCCGTTTTAAGAACCCTTATGGATCAATACAAACTGACTATTTCGGATTTTCAGGATGAAATTGGCAGTAAATCAAT
GGTTTCAAGGGTGTTGAACGGTCAACGTCAGCTGACGTTGAACCATATAAAAAAACTGGCTGCTCGCTTTGGGGTATCGC
CTGCGCTGTTCATTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I6CHB9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References