Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3969687..3970263 Replicon chromosome
Accession NZ_CP082929
Organism Salmonella enterica subsp. enterica serovar London isolate N18-04674

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag K6991_RS19175 Protein ID WP_001131963.1
Coordinates 3969976..3970263 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A5J0SGD3
Locus tag K6991_RS19170 Protein ID WP_023254955.1
Coordinates 3969687..3969989 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6991_RS19155 (3966197) 3966197..3968347 + 2151 WP_000379927.1 pyruvate/proton symporter BtsT -
K6991_RS19160 (3968442) 3968442..3968645 + 204 WP_000460616.1 YbdD/YjiX family protein -
K6991_RS19165 (3968656) 3968656..3969612 + 957 WP_000187838.1 GTPase -
K6991_RS19170 (3969687) 3969687..3969989 - 303 WP_023254955.1 BrnA antitoxin family protein Antitoxin
K6991_RS19175 (3969976) 3969976..3970263 - 288 WP_001131963.1 BrnT family toxin Toxin
K6991_RS19180 (3970532) 3970532..3971446 - 915 WP_000290515.1 restriction endonuclease -
K6991_RS19185 (3971644) 3971644..3975153 + 3510 WP_023256869.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(39-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T215647 WP_001131963.1 NZ_CP082929:c3970263-3969976 [Salmonella enterica subsp. enterica serovar London]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T215647 NZ_CP110861:c52577-52329 [Escherichia coli]
ATGAGAAAAAATAAAGGCGATGTGACTTATTTTCTTGAAAAAGAAGGTGACAATTACAGGCTTACAAAAAGGATAAAAGC
CAGAACAAATGTTAAAATCGGGAACAAAACTACGAAAATTACATTGTATGATGCCGTACTGAATGAGAATGAATTACAAC
ATATTGATTTTACGTGTGCCGGATTAAGGGAAGACGATGAGACGCCAGTTAAAAATTTAATTAAGGAGTTTATGTTAAAT
GAAACCTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11346.01 Da        Isoelectric Point: 10.1339

>AT215647 WP_023254955.1 NZ_CP082929:c3969989-3969687 [Salmonella enterica subsp. enterica serovar London]
MSMVKHKRGNACALSAQHEAELKALVKKSDDEIDYSDIPASEDGQWSGAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT215647 NZ_CP110861:c52339-52112 [Escherichia coli]
ATGAAACCTGATAATACACCTGAAAATGTAAAAAAATTACGTTTAAAAGCAGGATTAACACAAAAGGAATGCAGTCATAT
TTATGGTGTTGGGCTAAGAACCTGGCAGAAAAAAGAGGAAGTTAATACTCAAAACAGTCAAAGTCTGTCACTGGTTGAGT
TTGAGTTTCTTTTGTTACTTGCAGGAGAACATCCTGAATACGTGCTCTGCAAAAGGGAGTCAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A5J0SGD3

References