Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 832092..832752 Replicon chromosome
Accession NZ_CP082929
Organism Salmonella enterica subsp. enterica serovar London isolate N18-04674

Toxin (Protein)


Gene name cptA Uniprot ID A0A5I0Q7R2
Locus tag K6991_RS04000 Protein ID WP_023255487.1
Coordinates 832339..832752 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A3U5J6N8
Locus tag K6991_RS03995 Protein ID WP_058805755.1
Coordinates 832092..832358 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6991_RS03975 (828021) 828021..829454 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
K6991_RS03980 (829612) 829612..829923 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
K6991_RS03985 (830087) 830087..830746 + 660 WP_000250289.1 hemolysin III family protein -
K6991_RS03990 (830862) 830862..831842 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
K6991_RS03995 (832092) 832092..832358 + 267 WP_058805755.1 FAD assembly factor SdhE Antitoxin
K6991_RS04000 (832339) 832339..832752 + 414 WP_023255487.1 protein YgfX Toxin
K6991_RS04005 (832805) 832805..833326 - 522 WP_001055885.1 flavodoxin FldB -
K6991_RS04010 (833439) 833439..834335 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
K6991_RS04015 (834359) 834359..835072 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K6991_RS04020 (835078) 835078..836811 + 1734 WP_000813387.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16197.18 Da        Isoelectric Point: 10.7537

>T215632 WP_023255487.1 NZ_CP082929:832339-832752 [Salmonella enterica subsp. enterica serovar London]
VILWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T215632 NZ_CP110859:c1812516-1812142 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10608.09 Da        Isoelectric Point: 5.5844

>AT215632 WP_058805755.1 NZ_CP082929:832092-832358 [Salmonella enterica subsp. enterica serovar London]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERDPVAI

Download         Length: 267 bp

>AT215632 NZ_CP110859:c1812973-1812605 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I0Q7R2

Antitoxin

Source ID Structure
AlphaFold DB A0A3U5J6N8

References