Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 208614..209374 Replicon chromosome
Accession NZ_CP082929
Organism Salmonella enterica subsp. enterica serovar London isolate N18-04674

Toxin (Protein)


Gene name tacT Uniprot ID A0A5J1SP54
Locus tag K6991_RS00975 Protein ID WP_023256507.1
Coordinates 208889..209374 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag K6991_RS00970 Protein ID WP_000965886.1
Coordinates 208614..208901 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6991_RS00950 (204019) 204019..204930 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
K6991_RS00955 (204940) 204940..207009 + 2070 WP_023255847.1 glycine--tRNA ligase subunit beta -
K6991_RS00960 (207399) 207399..207797 + 399 Protein_190 IS3 family transposase -
K6991_RS00965 (207969) 207969..208436 + 468 WP_023256506.1 GNAT family N-acetyltransferase -
K6991_RS00970 (208614) 208614..208901 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
K6991_RS00975 (208889) 208889..209374 + 486 WP_023256507.1 GNAT family N-acetyltransferase Toxin
K6991_RS00980 (209745) 209745..210284 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
K6991_RS00985 (210458) 210458..210670 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
K6991_RS00990 (210958) 210958..211248 - 291 WP_000455790.1 HTH-type transcriptional regulator -
K6991_RS00995 (211687) 211687..212397 + 711 WP_000190524.1 DUF3053 domain-containing protein -
K6991_RS01000 (212447) 212447..213421 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
K6991_RS01005 (213640) 213640..214302 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(52-153)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17749.42 Da        Isoelectric Point: 9.7701

>T215630 WP_023256507.1 NZ_CP082929:208889-209374 [Salmonella enterica subsp. enterica serovar London]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVYKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVELSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQQTLFLRLP
Q

Download         Length: 486 bp

>T215630 NZ_CP110859:1800372-1800623 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT215630 WP_000965886.1 NZ_CP082929:208614-208901 [Salmonella enterica subsp. enterica serovar London]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT215630 NZ_CP110859:1800620-1800874 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5J1SP54

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References