Detailed information of TA system TA215625

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 4492345..4492889
• Replicon: chromosome
• Accession: NZ_CP082926
• Organism: Shewanella inventionis strain D1489

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K8B83_RS20170
• Protein ID: WP_188738946.1
• Coordinates: 4492345..4492644 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: K8B83_RS20175
• Protein ID: WP_188738947.1
• Coordinates: 4492632..4492889 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8B83_RS20140 (K8B83_20040)	4488238..4488612	+	375	WP_188738941.1	hypothetical protein	-
K8B83_RS20145 (K8B83_20045)	4488760..4489563	+	804	WP_188738942.1	hypothetical protein	-
K8B83_RS20150 (K8B83_20050)	4489564..4490634	-	1071	WP_188738943.1	diguanylate cyclase	-
K8B83_RS20155	4490950..4491201	+	252	WP_188738944.1	hypothetical protein	-
K8B83_RS20160 (K8B83_20055)	4491491..4491982	+	492	WP_188738945.1	DUF1097 domain-containing protein	-
K8B83_RS20165 (K8B83_20060)	4492138..4492314	+	177	Protein_3919	transposase domain-containing protein	-
K8B83_RS20170 (K8B83_20065)	4492345..4492644	-	300	WP_188738946.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K8B83_RS20175 (K8B83_20070)	4492632..4492889	-	258	WP_188738947.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
K8B83_RS20180 (K8B83_20075)	4493234..4493404	-	171	WP_188738948.1	hypothetical protein	-
K8B83_RS20185 (K8B83_20080)	4493587..4494564	-	978	WP_188738949.1	transposase	-
K8B83_RS20190 (K8B83_20085)	4494653..4494871	-	219	Protein_3924	transposase	-
K8B83_RS20195 (K8B83_20090)	4495075..4496412	-	1338	WP_223418768.1	group II intron reverse transcriptase/maturase	-
K8B83_RS20200 (K8B83_20095)	4496931..4497164	-	234	Protein_3926	transposase	-
K8B83_RS20205 (K8B83_20100)	4497244..4497615	-	372	WP_188738950.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11606.35 Da
• Isoelectric Point: 8.0184

>T215625 WP_188738946.1 NZ_CP082926:c4492644-4492345 [Shewanella inventionis]
MAEVVWTSPALDDLNDIAEYIALSNIQAAKKLTQKVFDKISRLESHPESGKRSPELINLNYREINVNPCRIFYKVDSDKV
YILHVMRQERDLRRFLIQS

Nucleotide

• Length: 300 bp

>T215625 NZ_CP110859:715026-715322 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9644.10 Da
• Isoelectric Point: 8.5496

>AT215625 WP_188738947.1 NZ_CP082926:c4492889-4492632 [Shewanella inventionis]
MRVELVTTLKRQATKILADLHTSKEPVLITEHGQPSAYLVDVEDYEFMQQRMAILEGVARGEQAIKNGNTFSNQEAKAKL
SKWLK

Nucleotide

• Length: 258 bp

>AT215625 NZ_CP110859:715324-715719 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA