Detailed information of TA system TA215620

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2926412..2927004
• Replicon: chromosome
• Accession: NZ_CP082926
• Organism: Shewanella inventionis strain D1489

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: K8B83_RS13015
• Protein ID: WP_188741155.1
• Coordinates: 2926750..2927004 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: K8B83_RS13010
• Protein ID: WP_188741154.1
• Coordinates: 2926412..2926753 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8B83_RS12985 (K8B83_12915)	2922890..2924146	-	1257	WP_223417392.1	Y-family DNA polymerase	-
K8B83_RS12990 (K8B83_12920)	2924159..2924566	-	408	WP_223417393.1	S24 family peptidase	-
K8B83_RS12995 (K8B83_12925)	2925329..2925616	-	288	WP_188741153.1	hypothetical protein	-
K8B83_RS13000 (K8B83_12930)	2925853..2925980	+	128	Protein_2546	IS66 family transposase	-
K8B83_RS13005	2926044..2926271	+	228	Protein_2547	ISAs1 family transposase	-
K8B83_RS13010 (K8B83_12935)	2926412..2926753	-	342	WP_188741154.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
K8B83_RS13015 (K8B83_12940)	2926750..2927004	-	255	WP_188741155.1	type II toxin-antitoxin system HicA family toxin	Toxin
K8B83_RS13020 (K8B83_12945)	2927088..2927273	-	186	WP_223417394.1	hypothetical protein	-
K8B83_RS13025	2927433..2927663	-	231	WP_223417395.1	GDCCVxC domain-containing (seleno)protein	-
K8B83_RS13030 (K8B83_12950)	2927645..2928040	-	396	WP_223417396.1	organomercurial transporter MerC	-
K8B83_RS13035 (K8B83_12955)	2928108..2928485	-	378	WP_188739080.1	MerR family transcriptional regulator	-
K8B83_RS13040 (K8B83_12960)	2928956..2930722	-	1767	WP_223417397.1	EAL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2903680..2941744	38064
	-	flank	IS/Tn	-	-	2931462..2932469	1007

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-74)

Antitoxin

• Uncharacterised protein family HicB (55-104)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9389.89 Da
• Isoelectric Point: 10.4023

>T215620 WP_188741155.1 NZ_CP082926:c2927004-2926750 [Shewanella inventionis]
MNKKHLRTLAAIFARPVSGSIKWSDIEALFIALGADIEEREGSRIGVVLFGEVQVYHRPHPHKETDKGAVVSVKKWLERN
GVKA

Nucleotide

• Length: 255 bp

>T215620 NZ_CP110857:c3904999-3904589 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12419.98 Da
• Isoelectric Point: 4.5037

>AT215620 WP_188741154.1 NZ_CP082926:c2926753-2926412 [Shewanella inventionis]
MKNLMMINGVKAFINFDPDAETFRGEFVGLNGGADFYGESINQLEAEGAKSLSVFLEMCQERGIEPYKNFSGKFNVRISP
EVHARLNEIALSQSISLNAAVENAVNDYIAHSA

Nucleotide

• Length: 342 bp

>AT215620 NZ_CP110857:c3905246-3904980 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA