Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1092846..1094488 Replicon chromosome
Accession NZ_CP082926
Organism Shewanella inventionis strain D1489

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K8B83_RS04995 Protein ID WP_188736155.1
Coordinates 1093163..1094488 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K8B83_RS04990 Protein ID WP_188736153.1
Coordinates 1092846..1093166 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B83_RS04960 (K8B83_04920) 1088235..1088579 + 345 WP_188736141.1 type II toxin-antitoxin system RelE/ParE family toxin -
K8B83_RS04965 (K8B83_04925) 1088581..1088856 + 276 WP_188736143.1 helix-turn-helix transcriptional regulator -
K8B83_RS04970 (K8B83_04930) 1089021..1089260 + 240 WP_188736145.1 hypothetical protein -
K8B83_RS04975 (K8B83_04935) 1089457..1089756 - 300 WP_188736147.1 type II toxin-antitoxin system RelE/ParE family toxin -
K8B83_RS04980 (K8B83_04940) 1089764..1090006 - 243 WP_188736149.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K8B83_RS04985 (K8B83_04945) 1090842..1092776 - 1935 WP_188736151.1 B12-binding domain-containing radical SAM protein -
K8B83_RS04990 (K8B83_04950) 1092846..1093166 - 321 WP_188736153.1 helix-turn-helix transcriptional regulator Antitoxin
K8B83_RS04995 (K8B83_04955) 1093163..1094488 - 1326 WP_188736155.1 HipA domain-containing protein Toxin
K8B83_RS05000 (K8B83_04960) 1094638..1095315 - 678 WP_188736157.1 monofunctional biosynthetic peptidoglycan transglycosylase -
K8B83_RS05005 (K8B83_04965) 1095475..1096107 - 633 WP_188736159.1 DsbA family protein -
K8B83_RS05010 (K8B83_04970) 1096285..1097562 + 1278 WP_188736161.1 glycerophosphodiester phosphodiesterase family protein -
K8B83_RS05015 (K8B83_04975) 1097894..1098847 + 954 WP_188736163.1 TAXI family TRAP transporter solute-binding subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-370)

Antitoxin

Cro/C1-type helix-turn-helix domain

(30-79)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50368.25 Da        Isoelectric Point: 5.1956

>T215619 WP_188736155.1 NZ_CP082926:c1094488-1093163 [Shewanella inventionis]
MKTLTIQALIQQQWLDIASLTLVNPKKGLSSQTRLGYELDYAVDWLNYNDEHACSLTLPIQIMIEHEADRWFGFLEDIAP
AGAARRYLVNYWGIQLLSPAEQDSFLLEKATIAPVGNLRIKQSLPTLPPDSTLHLRKFSVNDIVERESNFLEYAQEMGAI
SGGATGAGGEAPKLLLRVSEQDEIWIDTFQTQHDIADAHYLVKFPRGRRTQDDCDILRAEYHFYHELTAMGFNTISIKDM
KLLEGSRYPSLWLPRFDTAWNGNHWERFGLESIFSVLNEPAGSYLNHFMVIRSVCSVLQKQSNTFNTADFVCEWLTRDLL
NIAFGNSDNHGRNTALLKQPNNIWLSPIYDFAPMKLDPENVTRTTKWDPPFEEGGEYRWQAITDELNDLCPGETSLLALK
KTAEKLVGLQQRLHARGVPERVLDVIQVKWLDTKLARWGLI

Download         Length: 1326 bp

>T215619 NZ_CP110857:c3014636-3014283 [Enterobacter hormaechei]
GTGTGGGCGATTAAAACTACGGACAGGTTTGACGACTGGTTCACCTCATTAAACGATAGCGAGAGAGCCAGCGTACTGGC
CGCGCTACTTGTTTTGCGGGAGAGGGGACCGGGTCTGTCCAGACCGTATGCCGATACGCTGAAAGGCTCCCGCCACAGCA
ACATGAAAGAGTTGCGTATCCAGAGTAAGGGTGATCCGCTGAGGGCATTTTTCGCTTTCGATCCGAACCGTACGGGTATT
GTACTGTGTGCGGGCAATAAGGTCGGTAATGAAAGGCGATTTTACGATGAGATGCTCCTCGTTGCGGATCGGGAATACAC
TCGCTGGCTGAACACATTAAAAGAGAGGAATTAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11902.80 Da        Isoelectric Point: 10.0015

>AT215619 WP_188736153.1 NZ_CP082926:c1093166-1092846 [Shewanella inventionis]
MNMTAEQRQSLLITLLQQHLLGEVSQGEMLKRLRKEVLGMSQTRYAALVGVSRRTLTDIEQDKGSQAQSIIDKVFKPLGM
KSGLTPINTHIAKYVMTDTKQDESLN

Download         Length: 321 bp

>AT215619 NZ_CP110857:c3014278-3013976 [Enterobacter hormaechei]
ATGGGCAGAACCCTGGAGCAGCTTATTGCAGATGAAAAACCTGAGGTTGTTGCCAGCGCACAGGCAATGGCAACGGATAT
TTTGCTCAATATCCATCTGGCCGAGTTACGTGAAAAAGTGCAAAAAACGCAGGTAGATATGGCCAGGGCGTTGGGTATTA
AACAACCTACTGTCGCCGTCATGGAAAAGGCAGGACGCGATATTAAGCTTTCTTCTTTGAAACGCTACGTTGAGGCCGCC
GGAGGGAAGCTACGGCTGGATGTAGAACTACCCGATGGTTCTCATTACGAGTTTGTGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References