Detailed information of TA system TA215617

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /GNAT-DUF1778
• Location: 308710..309476
• Replicon: chromosome
• Accession: NZ_CP082926
• Organism: Shewanella inventionis strain D1489

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: K8B83_RS01460
• Protein ID: WP_223419986.1
• Coordinates: 308979..309476 (+)
• Length: 166 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: K8B83_RS01455
• Protein ID: WP_223419003.1
• Coordinates: 308710..308982 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8B83_RS01435 (K8B83_01430)	303752..304456	-	705	WP_223418996.1	histidine utilization repressor	-
K8B83_RS01440 (K8B83_01435)	304591..305823	+	1233	WP_223418998.1	imidazolonepropionase	-
K8B83_RS01445 (K8B83_01440)	306025..306801	+	777	WP_223419000.1	haloacid dehalogenase type II	-
K8B83_RS01450 (K8B83_01445)	306933..308600	+	1668	WP_223419002.1	amidohydrolase	-
K8B83_RS01455 (K8B83_01450)	308710..308982	+	273	WP_223419003.1	DUF1778 domain-containing protein	Antitoxin
K8B83_RS01460 (K8B83_01455)	308979..309476	+	498	WP_223419986.1	GNAT family N-acetyltransferase	Toxin
K8B83_RS01465 (K8B83_01460)	309851..310090	-	240	WP_188739003.1	YdcH family protein	-
K8B83_RS01470 (K8B83_01465)	310225..311436	-	1212	WP_223419005.1	alpha/beta hydrolase-fold protein	-
K8B83_RS01475 (K8B83_01470)	311638..312318	+	681	WP_223419007.1	acireductone synthase	-
K8B83_RS01480 (K8B83_01475)	312579..313001	+	423	WP_223419009.1	thioesterase family protein	-
K8B83_RS01485 (K8B83_01480)	313047..313304	+	258	WP_188739000.1	GNAT family N-acetyltransferase	-
K8B83_RS01490 (K8B83_01485)	313324..313731	-	408	WP_223419011.1	thioesterase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (86-150)

Antitoxin

• Vibrio phage ICP1, Orf50 (3-88)

Sequences

Toxin

Protein

• Length: 166 a.a.
• Molecular weight: 18579.33 Da
• Isoelectric Point: 9.7445

>T215617 WP_223419986.1 NZ_CP082926:308979-309476 [Shewanella inventionis]
IMNTVLLDKAKHDRNRFNCGSDALNNYLKVMASQQAKKDNTRTFVLEDDINNAHIIGFYTLTMTPIDIKALPHKLQKKYQ
SSTSGGLIARLAVDKRYKAQGFGEWLLIDALQKLLTASDSVAFPVVIVDAKDGAKHFYQRYGFQAFQDAEHKLFITIADV
RASLN

Nucleotide

• Length: 498 bp

>T215617 NZ_CP110857:c2773920-2773817 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9751.10 Da
• Isoelectric Point: 6.2990

>AT215617 WP_223419003.1 NZ_CP082926:308710-308982 [Shewanella inventionis]
MAATLPRITARVDADTQDLLSKAAALTGMSSINSFMLNAAIEKAKQVIEREETLKLNQADATLLMEALDRPATANSNLQA
ASERYKSKNQ

Nucleotide

• Length: 273 bp

>AT215617 NZ_CP110857:2773804-2774013 [Enterobacter hormaechei]
TTTTCAAGCAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGC
TAAAAGTTGGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGCA
AAAGTGGTCTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC