Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 308710..309476 Replicon chromosome
Accession NZ_CP082926
Organism Shewanella inventionis strain D1489

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag K8B83_RS01460 Protein ID WP_223419986.1
Coordinates 308979..309476 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag K8B83_RS01455 Protein ID WP_223419003.1
Coordinates 308710..308982 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B83_RS01435 (K8B83_01430) 303752..304456 - 705 WP_223418996.1 histidine utilization repressor -
K8B83_RS01440 (K8B83_01435) 304591..305823 + 1233 WP_223418998.1 imidazolonepropionase -
K8B83_RS01445 (K8B83_01440) 306025..306801 + 777 WP_223419000.1 haloacid dehalogenase type II -
K8B83_RS01450 (K8B83_01445) 306933..308600 + 1668 WP_223419002.1 amidohydrolase -
K8B83_RS01455 (K8B83_01450) 308710..308982 + 273 WP_223419003.1 DUF1778 domain-containing protein Antitoxin
K8B83_RS01460 (K8B83_01455) 308979..309476 + 498 WP_223419986.1 GNAT family N-acetyltransferase Toxin
K8B83_RS01465 (K8B83_01460) 309851..310090 - 240 WP_188739003.1 YdcH family protein -
K8B83_RS01470 (K8B83_01465) 310225..311436 - 1212 WP_223419005.1 alpha/beta hydrolase-fold protein -
K8B83_RS01475 (K8B83_01470) 311638..312318 + 681 WP_223419007.1 acireductone synthase -
K8B83_RS01480 (K8B83_01475) 312579..313001 + 423 WP_223419009.1 thioesterase family protein -
K8B83_RS01485 (K8B83_01480) 313047..313304 + 258 WP_188739000.1 GNAT family N-acetyltransferase -
K8B83_RS01490 (K8B83_01485) 313324..313731 - 408 WP_223419011.1 thioesterase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-150)

Antitoxin

Vibrio phage ICP1, Orf50

(3-88)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18579.33 Da        Isoelectric Point: 9.7445

>T215617 WP_223419986.1 NZ_CP082926:308979-309476 [Shewanella inventionis]
IMNTVLLDKAKHDRNRFNCGSDALNNYLKVMASQQAKKDNTRTFVLEDDINNAHIIGFYTLTMTPIDIKALPHKLQKKYQ
SSTSGGLIARLAVDKRYKAQGFGEWLLIDALQKLLTASDSVAFPVVIVDAKDGAKHFYQRYGFQAFQDAEHKLFITIADV
RASLN

Download         Length: 498 bp

>T215617 NZ_CP110857:c2773920-2773817 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9751.10 Da        Isoelectric Point: 6.2990

>AT215617 WP_223419003.1 NZ_CP082926:308710-308982 [Shewanella inventionis]
MAATLPRITARVDADTQDLLSKAAALTGMSSINSFMLNAAIEKAKQVIEREETLKLNQADATLLMEALDRPATANSNLQA
ASERYKSKNQ

Download         Length: 273 bp

>AT215617 NZ_CP110857:2773804-2774013 [Enterobacter hormaechei]
TTTTCAAGCAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGC
TAAAAGTTGGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGCA
AAAGTGGTCTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References