Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1379906..1380561 Replicon chromosome
Accession NZ_CP082923
Organism Caulobacter segnis strain CBR1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K8940_RS06400 Protein ID WP_223393890.1
Coordinates 1380166..1380561 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K8940_RS06395 Protein ID WP_223393888.1
Coordinates 1379906..1380166 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8940_RS06380 (K8940_06335) 1376932..1377546 + 615 WP_223393881.1 peptidylprolyl isomerase -
K8940_RS06385 (K8940_06340) 1377634..1377801 + 168 WP_223393884.1 hypothetical protein -
K8940_RS06390 (K8940_06345) 1377868..1379799 - 1932 WP_223393886.1 CocE/NonD family hydrolase -
K8940_RS06395 (K8940_06350) 1379906..1380166 + 261 WP_223393888.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K8940_RS06400 (K8940_06355) 1380166..1380561 + 396 WP_223393890.1 type II toxin-antitoxin system VapC family toxin Toxin
K8940_RS06405 (K8940_06360) 1380558..1381220 - 663 WP_223393892.1 phosphoribosylformylglycinamidine synthase subunit PurQ -
K8940_RS06410 (K8940_06365) 1381277..1381762 - 486 WP_223393894.1 DUF3291 domain-containing protein -
K8940_RS06415 (K8940_06370) 1381848..1382027 - 180 WP_223393896.1 rubredoxin -
K8940_RS06420 (K8940_06375) 1382035..1383309 - 1275 WP_223393899.1 cytochrome P450 -
K8940_RS06425 (K8940_06380) 1383393..1384016 + 624 WP_223393900.1 TetR/AcrR family transcriptional regulator -
K8940_RS06430 (K8940_06385) 1384025..1384264 - 240 WP_223393902.1 phosphoribosylformylglycinamidine synthase subunit PurS -
K8940_RS06435 (K8940_06390) 1384318..1385076 - 759 WP_223393904.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-85)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14015.99 Da        Isoelectric Point: 4.4452

>T215593 WP_223393890.1 NZ_CP082923:1380166-1380561 [Caulobacter segnis]
MVIDSSAMIAIESGEPEREAFLSAILSADTRLISAASYVECVAVMARRRPKSAAAVTVAATFRDLELVIVEVTVEQSRIA
AQALEDYGRTRHPAGLNYGDSFVYALAKVTGEPLLFKGDDFALTDVVAAAY

Download         Length: 396 bp

>T215593 NZ_CP110817:21164-21439 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGTCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTCAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9831.04 Da        Isoelectric Point: 5.2258

>AT215593 WP_223393888.1 NZ_CP082923:1379906-1380166 [Caulobacter segnis]
MAFSIKDPGTDRIVRNLARHTGLGLTETVRVAVENELKRRGADTRTIDEKVADFVRRLDRRDLGPDTGLSREEIEAEMYD
EYGLPR

Download         Length: 261 bp

>AT215593 NZ_CP110817:20880-21164 [Escherichia coli]
ATGCAAATGAAAAACAATAGTGCACAAGCAACAAAAGTAATTACCGCACATGTGCCATTACTTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGGCTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAAG
AGCGTAATCGCCTGACGCTGGAAGCCATGGACGATGTAACATCCGGACAGGTTATCAACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References