Detailed information of TA system TA215592

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 941237..941778
• Replicon: chromosome
• Accession: NZ_CP082923
• Organism: Caulobacter segnis strain CBR1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: K8940_RS04450
• Protein ID: WP_223393323.1
• Coordinates: 941237..941530 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: K8940_RS04455
• Protein ID: WP_223393324.1
• Coordinates: 941527..941778 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8940_RS04425 (K8940_04395)	937432..937953	-	522	Protein_879	AAA family ATPase	-
K8940_RS04430 (K8940_04400)	938005..938529	-	525	WP_223393319.1	GNAT family N-acetyltransferase	-
K8940_RS04435 (K8940_04405)	938622..939164	+	543	WP_223393320.1	methyltransferase domain-containing protein	-
K8940_RS04440 (K8940_04410)	939168..940379	-	1212	WP_223393321.1	YihY/virulence factor BrkB family protein	-
K8940_RS04445 (K8940_04415)	940472..941233	+	762	WP_223393322.1	MOSC N-terminal beta barrel domain-containing protein	-
K8940_RS04450 (K8940_04420)	941237..941530	-	294	WP_223393323.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K8940_RS04455 (K8940_04425)	941527..941778	-	252	WP_223393324.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
K8940_RS04460 (K8940_04430)	941867..942736	+	870	WP_223393325.1	peptide chain release factor N(5)-glutamine methyltransferase	-
K8940_RS04465 (K8940_04435)	942774..943001	+	228	Protein_887	hypothetical protein	-
K8940_RS04470 (K8940_04440)	942998..944101	+	1104	WP_223393326.1	DUF4167 domain-containing protein	-
K8940_RS04475 (K8940_04445)	944302..945366	+	1065	WP_223393327.1	PAS domain S-box protein	-
K8940_RS04480 (K8940_04450)	945377..945712	+	336	WP_223395766.1	response regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11346.77 Da
• Isoelectric Point: 8.5515

>T215592 WP_223393323.1 NZ_CP082923:c941530-941237 [Caulobacter segnis]
VSAYRLTPRAQRDFDEIWIYSKATWGGRRALAYLREIRATIALVAANPDLSPFDEDLPSGYRRRSTGSHFIFHRRQDDFI
EIVRVLHQNMDIDSHLS

Nucleotide

• Length: 294 bp

>T215592 NZ_CP110816:c4131952-4131779 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9271.25 Da
• Isoelectric Point: 4.2057

>AT215592 WP_223393324.1 NZ_CP082923:c941778-941527 [Caulobacter segnis]
MTKNTSIVLSEHFQSFIAEQVEDGRYGSASEVVRAGLRLLEDRETRLARLRAALLEGEQSGVAEEFDLDAFIADKAREEG
LEE

Nucleotide

• Length: 252 bp

>AT215592 NZ_CP110816:c4132276-4131980 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG