Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 941237..941778 Replicon chromosome
Accession NZ_CP082923
Organism Caulobacter segnis strain CBR1

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag K8940_RS04450 Protein ID WP_223393323.1
Coordinates 941237..941530 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag K8940_RS04455 Protein ID WP_223393324.1
Coordinates 941527..941778 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8940_RS04425 (K8940_04395) 937432..937953 - 522 Protein_879 AAA family ATPase -
K8940_RS04430 (K8940_04400) 938005..938529 - 525 WP_223393319.1 GNAT family N-acetyltransferase -
K8940_RS04435 (K8940_04405) 938622..939164 + 543 WP_223393320.1 methyltransferase domain-containing protein -
K8940_RS04440 (K8940_04410) 939168..940379 - 1212 WP_223393321.1 YihY/virulence factor BrkB family protein -
K8940_RS04445 (K8940_04415) 940472..941233 + 762 WP_223393322.1 MOSC N-terminal beta barrel domain-containing protein -
K8940_RS04450 (K8940_04420) 941237..941530 - 294 WP_223393323.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K8940_RS04455 (K8940_04425) 941527..941778 - 252 WP_223393324.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
K8940_RS04460 (K8940_04430) 941867..942736 + 870 WP_223393325.1 peptide chain release factor N(5)-glutamine methyltransferase -
K8940_RS04465 (K8940_04435) 942774..943001 + 228 Protein_887 hypothetical protein -
K8940_RS04470 (K8940_04440) 942998..944101 + 1104 WP_223393326.1 DUF4167 domain-containing protein -
K8940_RS04475 (K8940_04445) 944302..945366 + 1065 WP_223393327.1 PAS domain S-box protein -
K8940_RS04480 (K8940_04450) 945377..945712 + 336 WP_223395766.1 response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11346.77 Da        Isoelectric Point: 8.5515

>T215592 WP_223393323.1 NZ_CP082923:c941530-941237 [Caulobacter segnis]
VSAYRLTPRAQRDFDEIWIYSKATWGGRRALAYLREIRATIALVAANPDLSPFDEDLPSGYRRRSTGSHFIFHRRQDDFI
EIVRVLHQNMDIDSHLS

Download         Length: 294 bp

>T215592 NZ_CP110816:c4131952-4131779 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.25 Da        Isoelectric Point: 4.2057

>AT215592 WP_223393324.1 NZ_CP082923:c941778-941527 [Caulobacter segnis]
MTKNTSIVLSEHFQSFIAEQVEDGRYGSASEVVRAGLRLLEDRETRLARLRAALLEGEQSGVAEEFDLDAFIADKAREEG
LEE

Download         Length: 252 bp

>AT215592 NZ_CP110816:c4132276-4131980 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References