Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3803050..3803657 Replicon chromosome
Accession NZ_CP082922
Organism Nocardioides rotundus strain MCCC 1A10561

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K8W59_RS18680 Protein ID WP_223396499.1
Coordinates 3803050..3803448 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K8W59_RS18685 Protein ID WP_223396500.1
Coordinates 3803445..3803657 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8W59_RS18645 (K8W59_18695) 3798342..3798737 - 396 WP_223396493.1 type II toxin-antitoxin system VapC family toxin -
K8W59_RS18650 (K8W59_18700) 3798734..3799003 - 270 WP_223396494.1 type II toxin-antitoxin system VapB family antitoxin -
K8W59_RS18655 (K8W59_18705) 3799045..3799707 + 663 WP_223396495.1 VOC family protein -
K8W59_RS18660 (K8W59_18710) 3799711..3800070 - 360 WP_223396496.1 TraR/DksA C4-type zinc finger protein -
K8W59_RS18665 (K8W59_18715) 3800111..3800503 - 393 WP_223396497.1 DUF4186 domain-containing protein -
K8W59_RS18670 (K8W59_18720) 3800722..3802818 + 2097 WP_223399920.1 carbon starvation CstA family protein -
K8W59_RS18675 (K8W59_18725) 3802818..3803036 + 219 WP_223396498.1 YbdD/YjiX family protein -
K8W59_RS18680 (K8W59_18730) 3803050..3803448 - 399 WP_223396499.1 PIN domain nuclease Toxin
K8W59_RS18685 (K8W59_18735) 3803445..3803657 - 213 WP_223396500.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K8W59_RS18690 (K8W59_18740) 3803887..3805308 + 1422 WP_223396501.1 class I SAM-dependent methyltransferase -
K8W59_RS18695 (K8W59_18745) 3805466..3805861 - 396 WP_223396502.1 SRPBCC family protein -
K8W59_RS18700 (K8W59_18750) 3805936..3806148 + 213 WP_223396503.1 antitoxin -
K8W59_RS18705 (K8W59_18755) 3806152..3806589 + 438 WP_223396504.1 SRPBCC family protein -
K8W59_RS18710 (K8W59_18760) 3806591..3807622 - 1032 WP_223396505.1 TerC/Alx family metal homeostasis membrane protein -
K8W59_RS18715 (K8W59_18765) 3807773..3808375 - 603 WP_223396506.1 isoprenylcysteine carboxylmethyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3797178..3890247 93069


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(5-39)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14465.72 Da        Isoelectric Point: 4.7419

>T215590 WP_223396499.1 NZ_CP082922:c3803448-3803050 [Nocardioides rotundus]
VILVDTSAWVEFDRATGSDVDQTLTTLIAEDGPVAVTEPIVMEVCAGARSPARERDLRRLLGRFALLRFDPMADFDGAVT
VYRRCRRAGVTPRGLIDCMIAAVALRNDAQVLAMDRDFERLAEVVGLAMVGR

Download         Length: 399 bp

>T215590 NZ_CP110816:3950807-3951064 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7752.71 Da        Isoelectric Point: 4.3797

>AT215590 WP_223396500.1 NZ_CP082922:c3803657-3803445 [Nocardioides rotundus]
MARTRTNIEIENDYVVAIMDRYGVRTKTEAVDLALRHLAGDPMDRDEALAMRGARAIDQPPDDTPPADVA

Download         Length: 213 bp

>AT215590 NZ_CP110816:3951076-3951621 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References