Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3792301..3792977 Replicon chromosome
Accession NZ_CP082922
Organism Nocardioides rotundus strain MCCC 1A10561

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K8W59_RS18610 Protein ID WP_223396487.1
Coordinates 3792301..3792723 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K8W59_RS18615 Protein ID WP_223396488.1
Coordinates 3792723..3792977 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8W59_RS18580 (K8W59_18635) 3787951..3788625 - 675 WP_223396482.1 M15 family metallopeptidase -
K8W59_RS18585 (K8W59_18640) 3788694..3789044 - 351 WP_223396483.1 hypothetical protein -
K8W59_RS18590 (K8W59_18645) 3789071..3789661 - 591 WP_223396484.1 hypothetical protein -
K8W59_RS18595 (K8W59_18650) 3789674..3790378 - 705 WP_223396485.1 VOC family protein -
K8W59_RS18600 (K8W59_18655) 3790668..3791330 + 663 WP_223396486.1 class I SAM-dependent methyltransferase -
K8W59_RS18605 3791351..3791881 - 531 Protein_3659 phosphatase PAP2 family protein -
K8W59_RS18610 (K8W59_18660) 3792301..3792723 - 423 WP_223396487.1 PIN domain-containing protein Toxin
K8W59_RS18615 (K8W59_18665) 3792723..3792977 - 255 WP_223396488.1 hypothetical protein Antitoxin
K8W59_RS18620 (K8W59_18670) 3793058..3793606 - 549 WP_223396489.1 NAD(P)H-dependent oxidoreductase -
K8W59_RS18625 (K8W59_18675) 3793725..3794927 - 1203 WP_223396490.1 HNH endonuclease signature motif containing protein -
K8W59_RS18630 (K8W59_18680) 3795277..3795747 + 471 Protein_3664 chloramphenicol phosphotransferase CPT family protein -
K8W59_RS18635 (K8W59_18685) 3795874..3797316 - 1443 WP_223396491.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-133)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14908.04 Da        Isoelectric Point: 10.6637

>T215589 WP_223396487.1 NZ_CP082922:c3792723-3792301 [Nocardioides rotundus]
MLVLDTNVLIYAVHERSAQHGAARAWLTDSRGVGDRRDPVTVGSGVVRITTNPRVFSRPLPVEEALGAVRSWLAHPRVTV
PEPTRRHLDILAGLLETTGTAGNLTADAHLAALALEHGGAVASFDRGLARFGVRVVVPTP

Download         Length: 423 bp

>T215589 NZ_CP110816:3904245-3904586 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9281.44 Da        Isoelectric Point: 4.4978

>AT215589 WP_223396488.1 NZ_CP082922:c3792977-3792723 [Nocardioides rotundus]
MRTTITLDPDVAALLERDMRTRDVPFKRAVNEAIRRGLGAETAQVDVVFPSADLGQTSYELDHATALAAALEDEELVRKL
NEGR

Download         Length: 255 bp

>AT215589 NZ_CP110816:c3904250-3904174 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References