Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1232523..1233148 Replicon chromosome
Accession NZ_CP082922
Organism Nocardioides rotundus strain MCCC 1A10561

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K8W59_RS06135 Protein ID WP_223398073.1
Coordinates 1232523..1232924 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K8W59_RS06140 Protein ID WP_223398075.1
Coordinates 1232921..1233148 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8W59_RS06110 (K8W59_06100) 1227643..1227972 + 330 WP_223398056.1 antibiotic biosynthesis monooxygenase -
K8W59_RS06115 (K8W59_06105) 1227996..1229399 + 1404 WP_223398061.1 glycine--tRNA ligase -
K8W59_RS06120 (K8W59_06110) 1229425..1230135 + 711 WP_223398064.1 hypothetical protein -
K8W59_RS06125 (K8W59_06115) 1230187..1231326 + 1140 WP_223398067.1 tRNA dihydrouridine synthase DusB -
K8W59_RS06130 (K8W59_06120) 1231481..1232434 + 954 WP_223398070.1 hypothetical protein -
K8W59_RS06135 (K8W59_06125) 1232523..1232924 - 402 WP_223398073.1 type II toxin-antitoxin system VapC family toxin Toxin
K8W59_RS06140 (K8W59_06130) 1232921..1233148 - 228 WP_223398075.1 toxin-antitoxin system, antitoxin component Antitoxin
K8W59_RS06145 (K8W59_06135) 1233253..1234518 + 1266 WP_223398083.1 deoxyguanosinetriphosphate triphosphohydrolase -
K8W59_RS06150 (K8W59_06140) 1234526..1234858 - 333 WP_223398086.1 hypothetical protein -
K8W59_RS06155 (K8W59_06145) 1234958..1236853 + 1896 WP_223398090.1 DNA primase -
K8W59_RS06160 (K8W59_06150) 1236850..1237341 + 492 WP_223398094.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(3-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13744.70 Da        Isoelectric Point: 4.4983

>T215584 WP_223398073.1 NZ_CP082922:c1232924-1232523 [Nocardioides rotundus]
VIVLDASAAVEWLLARPDAAAVATRINDPDVALHAPSLLGVEVAAALRGLVRGGHASPERAVTALEDLAAAGIALHDPSP
LLPRAWELRDNLTPYDAVYVALAEVLDATLVTADARIARAPGLQAPVDVVTSH

Download         Length: 402 bp

>T215584 NZ_CP110816:2609763-2609870 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8293.47 Da        Isoelectric Point: 9.1275

>AT215584 WP_223398075.1 NZ_CP082922:c1233148-1232921 [Nocardioides rotundus]
MSMIQIRNVPEDVHRRLKARAALEGVSLSELALAELRRSLDRPTRQELLDLVASRTPVRTGPSSAELVEASRADS

Download         Length: 228 bp

>AT215584 NZ_CP110816:c2609713-2609650 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References