Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 299356..299909 Replicon chromosome
Accession NZ_CP082922
Organism Nocardioides rotundus strain MCCC 1A10561

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag K8W59_RS01430 Protein ID WP_223397000.1
Coordinates 299356..299637 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag K8W59_RS01435 Protein ID WP_223397001.1
Coordinates 299634..299909 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8W59_RS01405 (K8W59_01400) 294880..295509 - 630 WP_223396995.1 GNAT family N-acetyltransferase -
K8W59_RS01410 (K8W59_01405) 295575..296201 + 627 WP_223396996.1 DUF2461 domain-containing protein -
K8W59_RS01415 (K8W59_01410) 296222..297349 - 1128 WP_223396997.1 hypothetical protein -
K8W59_RS01420 (K8W59_01415) 297354..298604 - 1251 WP_223396998.1 C39 family peptidase -
K8W59_RS01425 (K8W59_01420) 298800..299231 + 432 WP_223396999.1 GNAT family N-acetyltransferase -
K8W59_RS01430 (K8W59_01425) 299356..299637 - 282 WP_223397000.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K8W59_RS01435 (K8W59_01430) 299634..299909 - 276 WP_223397001.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K8W59_RS01445 (K8W59_01440) 300147..300908 - 762 WP_223397002.1 SGNH/GDSL hydrolase family protein -
K8W59_RS01450 (K8W59_01445) 300959..301534 + 576 WP_223397003.1 dCTP deaminase -
K8W59_RS20100 301537..301668 - 132 WP_263283274.1 hypothetical protein -
K8W59_RS01455 (K8W59_01450) 301685..302506 - 822 WP_223397004.1 DUF4097 family beta strand repeat-containing protein -
K8W59_RS01460 (K8W59_01455) 302601..303122 - 522 WP_223397005.1 toxin-antitoxin system HicB family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-90)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10658.10 Da        Isoelectric Point: 11.0903

>T215582 WP_223397000.1 NZ_CP082922:c299637-299356 [Nocardioides rotundus]
VTEPGTEWRVEFSSAAVRSLDRLPEKVAAAVVEFTTGTLPTNPHRLSQQLQAELAGWRVARRGSYRVTFQILDQDRVLLV
GRIDHRADIYRRR

Download         Length: 282 bp

>T215582 NZ_CP110816:2608693-2608800 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9825.91 Da        Isoelectric Point: 4.5562

>AT215582 WP_223397001.1 NZ_CP082922:c299909-299634 [Nocardioides rotundus]
MKTVALSEAKDKLSALVDEAESTHEIITITRHGHNAAVLIAADELESMRETIRLLSTPGTVEELDRAREEYAAGGTTGGD
DLRSRFGLTSQ

Download         Length: 276 bp

>AT215582 NZ_CP110816:c2608646-2608580 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References