Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 287455..288091 Replicon chromosome
Accession NZ_CP082918
Organism Sutcliffiella horikoshii strain BAT

Toxin (Protein)


Gene name mazF Uniprot ID A0A0K6GQX7
Locus tag K7887_RS01535 Protein ID WP_010195163.1
Coordinates 287741..288091 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A0N0EA03
Locus tag K7887_RS01530 Protein ID WP_010195162.1
Coordinates 287455..287736 (+) Length 94 a.a.

Genomic Context

K7887_RS01515K7887_RS01520K7887_RS01525K7887_RS01530K7887_RS01535K7887_RS01540K7887_RS01545K7887_RS01550K7887_RS01555K7887_RS01560K7887_RS01565K7887_RS01570K7887_RS01510
Location: 284398..284763 (366 bp)
Type: Others
Protein ID: WP_223491880.1
Location: 284927..285949 (1023 bp)
Type: Others
Protein ID: WP_223491881.1
Location: 286140..287309 (1170 bp)
Type: Others
Protein ID: WP_223491882.1
Location: 287455..287736 (282 bp)
Type: Antitoxin
Protein ID: WP_010195162.1
Location: 287741..288091 (351 bp)
Type: Toxin
Protein ID: WP_010195163.1
Location: 288493..289323 (831 bp)
Type: Others
Protein ID: WP_223491883.1
Location: 289320..289676 (357 bp)
Type: Others
Protein ID: WP_010195165.1
Location: 289680..290081 (402 bp)
Type: Others
Protein ID: WP_010195167.1
Location: 290097..291104 (1008 bp)
Type: Others
Protein ID: WP_223491884.1
Location: 291181..291489 (309 bp)
Type: Others
Protein ID: WP_223491885.1
Location: 291538..292014 (477 bp)
Type: Others
Protein ID: WP_010195173.1
Location: 291989..292774 (786 bp)
Type: Others
Protein ID: WP_010195175.1
Location: 283566..284279 (714 bp)
Type: Others
Protein ID: WP_223491879.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K7887_RS01510 (K7887_01505)283566..284279-714WP_223491879.1rhomboid family intramembrane serine protease-
K7887_RS01515 (K7887_01510)284398..284763+366WP_223491880.1holo-ACP synthase-
K7887_RS01520 (K7887_01515)284927..285949+1023WP_223491881.1outer membrane lipoprotein carrier protein LolA-
K7887_RS01525 (K7887_01520)286140..287309+1170WP_223491882.1alanine racemase-
K7887_RS01530 (K7887_01525)287455..287736+282WP_010195162.1hypothetical proteinAntitoxin
K7887_RS01535 (K7887_01530)287741..288091+351WP_010195163.1type II toxin-antitoxin system endoribonuclease NdoAToxin
K7887_RS01540 (K7887_01535)288493..289323+831WP_223491883.1RsbT co-antagonist protein RsbRA-
K7887_RS01545 (K7887_01540)289320..289676+357WP_010195165.1STAS domain-containing protein-
K7887_RS01550 (K7887_01545)289680..290081+402WP_010195167.1anti-sigma regulatory factor-
K7887_RS01555 (K7887_01550)290097..291104+1008WP_223491884.1PP2C family protein-serine/threonine phosphatase-
K7887_RS01560 (K7887_01555)291181..291489+309WP_223491885.1STAS domain-containing protein-
K7887_RS01565 (K7887_01560)291538..292014+477WP_010195173.1anti-sigma B factor RsbW-
K7887_RS01570 (K7887_01565)291989..292774+786WP_010195175.1RNA polymerase sigma factor SigB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13006.03 Da        Isoelectric Point: 4.8891

>T215581 WP_010195163.1 NZ_CP082918:287741-288091 [Sutcliffiella horikoshii]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDEEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T215581 NZ_CP110816:c2370174-2369998 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10717.21 Da        Isoelectric Point: 7.0161

>AT215581 WP_010195162.1 NZ_CP082918:287455-287736 [Sutcliffiella horikoshii]
VSESSATTEILIRLPQNLVSELDGLVKQENGNRNELIFQATKMYLRERKKRQIRESMRRGYMEMSKINLNIASEAFLAEY
EAEHTVERLVSGG

Download         Length: 282 bp

>AT215581 NZ_CP110816:c2369952-2369536 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K6GQX7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0N0EA03

References