215581

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 287455..288091 Replicon chromosome
Accession NZ_CP082918
Organism Sutcliffiella horikoshii strain BAT

Toxin (Protein)


Gene name mazF Uniprot ID A0A0K6GQX7
Locus tag K7887_RS01535 Protein ID WP_010195163.1
Coordinates 287741..288091 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A0N0EA03
Locus tag K7887_RS01530 Protein ID WP_010195162.1
Coordinates 287455..287736 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7887_RS01510 (K7887_01505) 283566..284279 - 714 WP_223491879.1 rhomboid family intramembrane serine protease -
K7887_RS01515 (K7887_01510) 284398..284763 + 366 WP_223491880.1 holo-ACP synthase -
K7887_RS01520 (K7887_01515) 284927..285949 + 1023 WP_223491881.1 outer membrane lipoprotein carrier protein LolA -
K7887_RS01525 (K7887_01520) 286140..287309 + 1170 WP_223491882.1 alanine racemase -
K7887_RS01530 (K7887_01525) 287455..287736 + 282 WP_010195162.1 hypothetical protein Antitoxin
K7887_RS01535 (K7887_01530) 287741..288091 + 351 WP_010195163.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
K7887_RS01540 (K7887_01535) 288493..289323 + 831 WP_223491883.1 RsbT co-antagonist protein RsbRA -
K7887_RS01545 (K7887_01540) 289320..289676 + 357 WP_010195165.1 STAS domain-containing protein -
K7887_RS01550 (K7887_01545) 289680..290081 + 402 WP_010195167.1 anti-sigma regulatory factor -
K7887_RS01555 (K7887_01550) 290097..291104 + 1008 WP_223491884.1 PP2C family protein-serine/threonine phosphatase -
K7887_RS01560 (K7887_01555) 291181..291489 + 309 WP_223491885.1 STAS domain-containing protein -
K7887_RS01565 (K7887_01560) 291538..292014 + 477 WP_010195173.1 anti-sigma B factor RsbW -
K7887_RS01570 (K7887_01565) 291989..292774 + 786 WP_010195175.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13006.03 Da        Isoelectric Point: 4.8891

>T215581 WP_010195163.1 NZ_CP082918:287741-288091 [Sutcliffiella horikoshii]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDEEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T215581 NZ_CP110816:c2370174-2369998 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10717.21 Da        Isoelectric Point: 7.0161

>AT215581 WP_010195162.1 NZ_CP082918:287455-287736 [Sutcliffiella horikoshii]
VSESSATTEILIRLPQNLVSELDGLVKQENGNRNELIFQATKMYLRERKKRQIRESMRRGYMEMSKINLNIASEAFLAEY
EAEHTVERLVSGG

Download         Length: 282 bp

>AT215581 NZ_CP110816:c2369952-2369536 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K6GQX7

Antitoxin

Source ID Structure
AlphaFold DB A0A0N0EA03

References