Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 14753..15278 | Replicon | plasmid p_ZC-S1_3rd |
| Accession | NZ_CP082917 | ||
| Organism | Salmonella enterica subsp. enterica serovar Newlands strain ZC-S1 3rd | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | I3W3D5 |
| Locus tag | K8862_RS22850 | Protein ID | WP_001159863.1 |
| Coordinates | 14753..15058 (-) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | M7S5D0 |
| Locus tag | K8862_RS22855 | Protein ID | WP_000813641.1 |
| Coordinates | 15060..15278 (-) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8862_RS22810 (K8862_22705) | 10132..10692 | - | 561 | WP_000900095.1 | inverse autotransporter beta domain-containing protein | - |
| K8862_RS22815 (K8862_22710) | 10848..11135 | + | 288 | WP_071530243.1 | hypothetical protein | - |
| K8862_RS22820 (K8862_22715) | 11412..11897 | - | 486 | WP_000905606.1 | membrane protein | - |
| K8862_RS22825 (K8862_22720) | 11891..12379 | - | 489 | WP_001075507.1 | CaiF/GrlA family transcriptional regulator | - |
| K8862_RS22830 (K8862_22725) | 12404..13117 | - | 714 | WP_000545756.1 | EAL domain-containing protein | - |
| K8862_RS22835 (K8862_22730) | 13126..13908 | - | 783 | WP_000082169.1 | site-specific integrase | - |
| K8862_RS22840 (K8862_22735) | 13943..14464 | - | 522 | WP_000198608.1 | hypothetical protein | - |
| K8862_RS22845 (K8862_22740) | 14461..14751 | - | 291 | WP_001266176.1 | hypothetical protein | - |
| K8862_RS22850 (K8862_22745) | 14753..15058 | - | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| K8862_RS22855 (K8862_22750) | 15060..15278 | - | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| K8862_RS22860 (K8862_22755) | 15954..16475 | + | 522 | WP_077681952.1 | hypothetical protein | - |
| K8862_RS22865 (K8862_22760) | 16519..16947 | - | 429 | Protein_23 | hypothetical protein | - |
| K8862_RS22870 (K8862_22765) | 16959..17254 | + | 296 | Protein_24 | cytoplasmic protein | - |
| K8862_RS22875 (K8862_22770) | 17748..18737 | + | 990 | WP_000461382.1 | RepB family plasmid replication initiator protein | - |
| K8862_RS22880 (K8862_22775) | 19106..19225 | - | 120 | Protein_26 | recombinase | - |
| K8862_RS22885 (K8862_22780) | 19278..19664 | - | 387 | WP_000751876.1 | YgiW/YdeI family stress tolerance OB fold protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | spvB / spvC / fdeC / pefB / pefA / pefC / pefD / rck | 1..59361 | 59361 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11587.48 Da Isoelectric Point: 6.9787
>T215580 WP_001159863.1 NZ_CP082917:c15058-14753 [Salmonella enterica subsp. enterica serovar Newlands]
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
Download Length: 306 bp
>T215580 NZ_CP082917:c15058-14753 [Salmonella enterica subsp. enterica serovar Newlands]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8314.16 Da Isoelectric Point: 4.5203
>AT215580 WP_000813641.1 NZ_CP082917:c15278-15060 [Salmonella enterica subsp. enterica serovar Newlands]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
Download Length: 219 bp
>AT215580 NZ_CP082917:c15278-15060 [Salmonella enterica subsp. enterica serovar Newlands]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGACAACAGGAACTGGTGA
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGACAACAGGAACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | I3W3D5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656ICA6 |