Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3090154..3090814 Replicon chromosome
Accession NZ_CP082916
Organism Salmonella enterica subsp. enterica serovar Newlands strain ZC-S1 3rd

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag K8862_RS14985 Protein ID WP_000244756.1
Coordinates 3090401..3090814 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag K8862_RS14980 Protein ID WP_000351186.1
Coordinates 3090154..3090420 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8862_RS14960 (3086083) 3086083..3087516 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
K8862_RS14965 (3087674) 3087674..3087985 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
K8862_RS14970 (3088149) 3088149..3088808 + 660 WP_000250289.1 hemolysin III family protein -
K8862_RS14975 (3088924) 3088924..3089904 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
K8862_RS14980 (3090154) 3090154..3090420 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
K8862_RS14985 (3090401) 3090401..3090814 + 414 WP_000244756.1 protein YgfX Toxin
K8862_RS14990 (3090867) 3090867..3091388 - 522 WP_001055885.1 flavodoxin FldB -
K8862_RS14995 (3091501) 3091501..3092397 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
K8862_RS15000 (3092421) 3092421..3093134 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K8862_RS15005 (3093140) 3093140..3094873 + 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T215577 WP_000244756.1 NZ_CP082916:3090401-3090814 [Salmonella enterica subsp. enterica serovar Newlands]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T215577 NZ_CP110816:c1802667-1802293 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT215577 WP_000351186.1 NZ_CP082916:3090154-3090420 [Salmonella enterica subsp. enterica serovar Newlands]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT215577 NZ_CP110816:c1803124-1802756 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References