Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1657609..1658125 Replicon chromosome
Accession NZ_CP082916
Organism Salmonella enterica subsp. enterica serovar Newlands strain ZC-S1 3rd

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag K8862_RS08155 Protein ID WP_000220582.1
Coordinates 1657609..1657893 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag K8862_RS08160 Protein ID WP_000212724.1
Coordinates 1657883..1658125 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8862_RS08140 (1652820) 1652820..1654472 + 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -
K8862_RS08145 (1654881) 1654881..1657019 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
K8862_RS08150 (1657141) 1657141..1657605 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K8862_RS08155 (1657609) 1657609..1657893 - 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K8862_RS08160 (1657883) 1657883..1658125 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K8862_RS08165 (1658203) 1658203..1660116 - 1914 WP_001212142.1 BglG family transcription antiterminator -
K8862_RS08170 (1660133) 1660133..1660873 - 741 WP_187788438.1 KDGP aldolase family protein -
K8862_RS08175 (1660870) 1660870..1661988 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
K8862_RS08180 (1661972) 1661972..1663105 - 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T215570 WP_000220582.1 NZ_CP082916:c1657893-1657609 [Salmonella enterica subsp. enterica serovar Newlands]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T215570 NZ_CP110816:717224-717520 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT215570 WP_000212724.1 NZ_CP082916:c1658125-1657883 [Salmonella enterica subsp. enterica serovar Newlands]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT215570 NZ_CP110816:717522-717917 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References