Detailed information of TA system TA215569

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 1616484..1617034
• Replicon: chromosome
• Accession: NZ_CP082916
• Organism: Salmonella enterica subsp. enterica serovar Newlands strain ZC-S1 3rd

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: M7RJ32
• Locus tag: K8862_RS07935
• Protein ID: WP_001199743.1
• Coordinates: 1616484..1616792 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7RP97
• Locus tag: K8862_RS07940
• Protein ID: WP_001118105.1
• Coordinates: 1616795..1617034 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8862_RS07915 (1613058)	1613058..1613798	-	741	WP_001676217.1	SEF14/SEF18 fimbria chaperone SefB	-
K8862_RS07920 (1613920)	1613920..1614450	-	531	WP_000909461.1	SEF14 fimbria major subunit SefA	-
K8862_RS07925 (1614773)	1614773..1615906	+	1134	Protein_1545	IS3 family transposase	-
K8862_RS07930 (1615938)	1615938..1616078	-	141	Protein_1546	Arm DNA-binding domain-containing protein	-
K8862_RS07935 (1616484)	1616484..1616792	-	309	WP_001199743.1	CcdB family protein	Toxin
K8862_RS07940 (1616795)	1616795..1617034	-	240	WP_001118105.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
K8862_RS07945 (1617143)	1617143..1617391	-	249	WP_000168388.1	ribbon-helix-helix domain-containing protein	-
K8862_RS07950 (1617582)	1617582..1618013	-	432	Protein_1550	helix-turn-helix domain-containing protein	-
K8862_RS07965 (1618770)	1618770..1619789	+	1020	WP_000152558.1	NAD(P)-dependent alcohol dehydrogenase	-
K8862_RS07970 (1619817)	1619817..1620347	-	531	WP_000896758.1	gluconokinase	-
K8862_RS07975 (1620564)	1620564..1621595	+	1032	WP_000453347.1	L-idonate 5-dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	1614865..1617968	3103

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-101)

Antitoxin

• Post-segregation antitoxin CcdA (9-79)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11845.67 Da
• Isoelectric Point: 6.7228

>T215569 WP_001199743.1 NZ_CP082916:c1616792-1616484 [Salmonella enterica subsp. enterica serovar Newlands]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Nucleotide

• Length: 309 bp

>T215569 NZ_CP110816:651314-651628 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8719.90 Da
• Isoelectric Point: 6.4633

>AT215569 WP_001118105.1 NZ_CP082916:c1617034-1616795 [Salmonella enterica subsp. enterica serovar Newlands]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Nucleotide

• Length: 240 bp

>AT215569 NZ_CP110816:651625-652041 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Structures

Toxin

• AlphaFold DB: A0A6C6Z9V9

Antitoxin

• AlphaFold DB: A0A5H9SZK8