Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 996693..997313 Replicon chromosome
Accession NZ_CP082916
Organism Salmonella enterica subsp. enterica serovar Newlands strain ZC-S1 3rd

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag K8862_RS05075 Protein ID WP_001280991.1
Coordinates 997095..997313 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag K8862_RS05070 Protein ID WP_000344807.1
Coordinates 996693..997067 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8862_RS05060 (991832) 991832..993025 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K8862_RS05065 (993048) 993048..996197 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
K8862_RS05070 (996693) 996693..997067 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
K8862_RS05075 (997095) 997095..997313 + 219 WP_001280991.1 HHA domain-containing protein Toxin
K8862_RS05080 (997492) 997492..998043 + 552 WP_001278793.1 maltose O-acetyltransferase -
K8862_RS05085 (998161) 998161..998631 + 471 WP_000136183.1 YlaC family protein -
K8862_RS05090 (998687) 998687..998827 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
K8862_RS05095 (998833) 998833..999093 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
K8862_RS05100 (999318) 999318..1000868 + 1551 WP_000213140.1 EAL domain-containing protein -
K8862_RS05110 (1001099) 1001099..1001488 + 390 WP_000961287.1 MGMT family protein -
K8862_RS05115 (1001521) 1001521..1002090 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T215564 WP_001280991.1 NZ_CP082916:997095-997313 [Salmonella enterica subsp. enterica serovar Newlands]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T215564 NZ_CP110815:51739-52020 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAGCTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTTTATCAGATTGCAGATATGCGCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT215564 WP_000344807.1 NZ_CP082916:996693-997067 [Salmonella enterica subsp. enterica serovar Newlands]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT215564 NZ_CP110815:51498-51749 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References