Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5451720..5452319 Replicon chromosome
Accession NZ_CP082909
Organism Endozoicomonas sp. 4G

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag K7B67_RS21640 Protein ID WP_256484613.1
Coordinates 5452152..5452319 (-) Length 56 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag K7B67_RS21635 Protein ID WP_252177915.1
Coordinates 5451720..5452118 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7B67_RS21620 5446940..5450485 + 3546 WP_252177912.1 chemotaxis protein CheA -
K7B67_RS21625 5450469..5450981 + 513 WP_252177913.1 chemotaxis protein CheW -
K7B67_RS21630 5450953..5451678 - 726 WP_252177914.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
K7B67_RS21635 5451720..5452118 - 399 WP_252177915.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K7B67_RS21640 5452152..5452319 - 168 WP_256484613.1 type II toxin-antitoxin system HicA family toxin Toxin
K7B67_RS21645 5452540..5452998 + 459 WP_252177916.1 hypothetical protein -
K7B67_RS21650 5453051..5453776 - 726 WP_252177917.1 phosphate signaling complex protein PhoU -
K7B67_RS21655 5453800..5454699 - 900 WP_252177918.1 phosphate ABC transporter ATP-binding protein PstB -
K7B67_RS21660 5454749..5456413 - 1665 WP_252177919.1 phosphate ABC transporter permease PstA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(1-54)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 56 a.a.        Molecular weight: 6236.40 Da        Isoelectric Point: 10.7918

>T215552 WP_256484613.1 NZ_CP082909:c5452319-5452152 [Endozoicomonas sp. 4G]
MIKMLEKDGWELTRINGSHHIFKHPVKKGTPSVPHPKQGLPKGTVRNILKEAELI

Download         Length: 168 bp

>T215552 NZ_CP110814:2608804-2608911 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14648.43 Da        Isoelectric Point: 4.2855

>AT215552 WP_252177915.1 NZ_CP082909:c5452118-5451720 [Endozoicomonas sp. 4G]
MLYPIVIHKDPDSAYGVTVPDIKGCFSAGDTFAEALECTKEAINGYLEMFTEEGKPIPNGSDIDDLVDNPDYEGGTWALV
EVDITPYLGKTEKINVTLPSSLIRKIDDEVRKHSSQYRSRSSFLAQAAFREL

Download         Length: 399 bp

>AT215552 NZ_CP110814:c2608757-2608691 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References