Detailed information of TA system TA215549

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-DUF971
• Location: 5177875..5178463
• Replicon: chromosome
• Accession: NZ_CP082909
• Organism: Endozoicomonas sp. 4G

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: K7B67_RS20455
• Protein ID: WP_252177702.1
• Coordinates: 5177875..5178180 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: K7B67_RS20460
• Protein ID: WP_252177703.1
• Coordinates: 5178173..5178463 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K7B67_RS20440	5176706..5176936	-	231	WP_252177699.1	helix-turn-helix domain-containing protein	-
K7B67_RS20445	5177007..5177459	+	453	WP_252177700.1	IS200/IS605 family transposase	-
K7B67_RS20450	5177582..5177824	-	243	WP_252177701.1	hypothetical protein	-
K7B67_RS20455	5177875..5178180	+	306	WP_252177702.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K7B67_RS20460	5178173..5178463	+	291	WP_252177703.1	putative addiction module antidote protein	Antitoxin
K7B67_RS20465	5178485..5179648	-	1164	WP_252177704.1	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-96)

Antitoxin

• Uncharacterized protein HI1420 (12-92)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11475.21 Da
• Isoelectric Point: 10.1896

>T215549 WP_252177702.1 NZ_CP082909:5177875-5178180 [Endozoicomonas sp. 4G]
MITIKETETYRKWERKLKNARAKAIIAARVFRLANGLPGDVAPVGQGISELRVHYGPGYRVYFRQQGNEIILLLCGGDKS
TQSKDIELAKQLAQEWRKSDD

Nucleotide

• Length: 306 bp

>T215549 NZ_CP110814:2233938-2234225 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10364.70 Da
• Isoelectric Point: 4.5203

>AT215549 WP_252177703.1 NZ_CP082909:5178173-5178463 [Endozoicomonas sp. 4G]
MTEPVYTYDPAAALDSPEAREVFIADAFETGDASYIAKALGVVARAEGMSNIARQTGLSREQLYRSFSEDGNPTLKTILN
VMKALGFTITATKNLT

Nucleotide

• Length: 291 bp

>AT215549 NZ_CP110814:2233699-2233938 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA