Detailed information of TA system TA215548

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 5127134..5127859
• Replicon: chromosome
• Accession: NZ_CP082909
• Organism: Endozoicomonas sp. 4G

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: K7B67_RS20275
• Protein ID: WP_256484592.1
• Coordinates: 5127134..5127331 (+)
• Length: 66 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: K7B67_RS20280
• Protein ID: WP_252177668.1
• Coordinates: 5127452..5127859 (+)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K7B67_RS20260	5123258..5125423	-	2166	WP_252177664.1	DNA helicase II	-
K7B67_RS20265	5125712..5125891	+	180	WP_252177665.1	hypothetical protein	-
K7B67_RS20270	5126106..5127023	+	918	WP_252177666.1	zinc ABC transporter substrate-binding protein ZnuA	-
K7B67_RS20275	5127134..5127331	+	198	WP_256484592.1	type II toxin-antitoxin system HicA family toxin	Toxin
K7B67_RS20280	5127452..5127859	+	408	WP_252177668.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
K7B67_RS20285	5127982..5128248	-	267	WP_252177669.1	Lar family restriction alleviation protein	-
K7B67_RS20290	5128355..5130763	-	2409	WP_252177670.1	right-handed parallel beta-helix repeat-containing protein	-
K7B67_RS20295	5130895..5132292	-	1398	WP_252177671.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 66 a.a.
• Molecular weight: 7409.63 Da
• Isoelectric Point: 11.2092

>T215548 WP_256484592.1 NZ_CP082909:5127134-5127331 [Endozoicomonas sp. 4G]
MKSREIIRMLEDAGWVLHRVKGSHHHFKHSERPGLVTVPHPKHDISKKTLDSIRKQAGMKNPPAG

Nucleotide

• Length: 198 bp

>T215548 NZ_CP110814:1956364-1956467 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15012.94 Da
• Isoelectric Point: 4.1657

>AT215548 WP_252177668.1 NZ_CP082909:5127452-5127859 [Endozoicomonas sp. 4G]
MKYPVVLHTDDGENYSVMVPDIEGCFSAGSSIEEALANAKEAIEGHLEILAEDEMTIPEAGRIADHQNNPDYEGGIWALV
DVDITPFLGKSERINITLPILLLRQIDKLVEADPAYRTRSGFLQEVARDKLRSME

Nucleotide

• Length: 408 bp

>AT215548 NZ_CP110814:c1956505-1956234 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT