Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4900219..4900841 Replicon chromosome
Accession NZ_CP082909
Organism Endozoicomonas sp. 4G

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag K7B67_RS19205 Protein ID WP_252180613.1
Coordinates 4900686..4900841 (-) Length 52 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag K7B67_RS19200 Protein ID WP_252177473.1
Coordinates 4900219..4900620 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7B67_RS19175 4896799..4897110 - 312 WP_252177469.1 stress response translation initiation inhibitor YciH -
K7B67_RS19180 4897119..4897709 - 591 WP_252177470.1 HD domain-containing protein -
K7B67_RS19185 4897827..4898561 - 735 WP_252177471.1 hypothetical protein -
K7B67_RS19190 4898558..4898983 - 426 WP_252177472.1 hypothetical protein -
K7B67_RS19195 4899039..4900019 - 981 WP_252180612.1 DUF2333 family protein -
K7B67_RS19200 4900219..4900620 - 402 WP_252177473.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K7B67_RS19205 4900686..4900841 - 156 WP_252180613.1 type II toxin-antitoxin system HicA family toxin Toxin
K7B67_RS19215 4902559..4902789 - 231 WP_252177474.1 hypothetical protein -
K7B67_RS19220 4902868..4904463 - 1596 WP_252177475.1 YfjI family protein -
K7B67_RS19225 4904450..4905451 - 1002 WP_252177476.1 primase-helicase zinc-binding domain-containing protein -
K7B67_RS19230 4905584..4905835 - 252 WP_252177477.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4900219..4916771 16552


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(1-50)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5824.85 Da        Isoelectric Point: 11.4350

>T215546 WP_252180613.1 NZ_CP082909:c4900841-4900686 [Endozoicomonas sp. 4G]
MEAAGWKLDRVRGSHHIFKHPDFNRSVPIPHPKKDLKQGTLKAIRKQAGLI

Download         Length: 156 bp

>T215546 NZ_CP110814:1790882-1791136 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14527.57 Da        Isoelectric Point: 4.2216

>AT215546 WP_252177473.1 NZ_CP082909:c4900620-4900219 [Endozoicomonas sp. 4G]
MKYPIAIEWGDDEHATGIAIPDIPGAITAGDTYEEAYKGAVEVAHIMLEEMVGNGEEVPLPSPVKDLMVNPDYEGWGWGL
IEVDLSPYLGKTEKINVTLPGVLVNKIDSYVKSHDVKSRSAFLADAAMEKLRL

Download         Length: 402 bp

>AT215546 NZ_CP110814:1790634-1790885 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References