Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2671188..2671827 Replicon chromosome
Accession NZ_CP082909
Organism Endozoicomonas sp. 4G

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K7B67_RS10625 Protein ID WP_252180307.1
Coordinates 2671188..2671607 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K7B67_RS10630 Protein ID WP_252180308.1
Coordinates 2671594..2671827 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7B67_RS10595 2666865..2667860 - 996 WP_252180301.1 transposase -
K7B67_RS10600 2667976..2668305 - 330 WP_252180302.1 DUF5615 family PIN-like protein -
K7B67_RS10605 2668305..2668526 - 222 WP_252180303.1 DUF433 domain-containing protein -
K7B67_RS10610 2669028..2669315 + 288 WP_252180304.1 hypothetical protein -
K7B67_RS10615 2669494..2669907 - 414 WP_252180305.1 hypothetical protein -
K7B67_RS10620 2670367..2670588 + 222 WP_252180306.1 DUF433 domain-containing protein -
K7B67_RS10625 2671188..2671607 - 420 WP_252180307.1 type II toxin-antitoxin system VapC family toxin Toxin
K7B67_RS10630 2671594..2671827 - 234 WP_252180308.1 DNA-binding protein Antitoxin
K7B67_RS10635 2672218..2672919 - 702 WP_252180309.1 hypothetical protein -
K7B67_RS10640 2673158..2674240 - 1083 WP_252176869.1 group II intron reverse transcriptase/maturase -
K7B67_RS10645 2674204..2674482 - 279 WP_252176870.1 hypothetical protein -
K7B67_RS10650 2675000..2676220 - 1221 WP_252180310.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2640267..2672919 32652


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16058.38 Da        Isoelectric Point: 8.4689

>T215543 WP_252180307.1 NZ_CP082909:c2671607-2671188 [Endozoicomonas sp. 4G]
MYLIDTNVISELRKKKRASPGIIDFFQKTEQQMQPIYLSVITLGELRRGVEKIRYRGDQSQAQQLESWLNNLVKDFTHRI
LEFGDTEAQLWGRLRVPHHENAIDKQIAATALAYDLILVTRNTNDFSGTGVKLLNPFLE

Download         Length: 420 bp

>T215543 NZ_CP110814:c1108426-1108097 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8792.99 Da        Isoelectric Point: 10.0825

>AT215543 WP_252180308.1 NZ_CP082909:c2671827-2671594 [Endozoicomonas sp. 4G]
MANLIVRNIDDRIVDALKARAGQHGRSAEAEHRRILETALLRPRKKTLAEALKSIPNVGKDTDFERINDKEDRDVFN

Download         Length: 234 bp

>AT215543 NZ_CP110814:c1108764-1108447 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References