215541

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2542409..2543439 Replicon chromosome
Accession NZ_CP082909
Organism Endozoicomonas sp. 4G

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag K7B67_RS09870 Protein ID WP_252180167.1
Coordinates 2542409..2542981 (-) Length 191 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag K7B67_RS09875 Protein ID WP_252180168.1
Coordinates 2542981..2543439 (-) Length 153 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7B67_RS09845 2539531..2539833 - 303 WP_256484819.1 type II toxin-antitoxin system RelE/ParE family toxin -
K7B67_RS09850 2539839..2540081 - 243 WP_252180163.1 type II toxin-antitoxin system ParD family antitoxin -
K7B67_RS09855 2540143..2540424 + 282 WP_252180164.1 type IV conjugative transfer system protein TraL -
K7B67_RS09860 2540521..2540892 + 372 WP_252180165.1 winged helix-turn-helix domain-containing protein -
K7B67_RS09865 2541317..2542282 + 966 WP_252180166.1 helix-turn-helix transcriptional regulator -
K7B67_RS09870 2542409..2542981 - 573 WP_252180167.1 PIN domain-containing protein Toxin
K7B67_RS09875 2542981..2543439 - 459 WP_252180168.1 helix-turn-helix domain-containing protein Antitoxin
K7B67_RS09880 2543481..2543741 - 261 WP_252180169.1 hypothetical protein -
K7B67_RS09885 2543834..2544388 + 555 WP_252180170.1 type IV conjugative transfer system protein TraE -
K7B67_RS09890 2544416..2545183 + 768 WP_252180171.1 type-F conjugative transfer system secretin TraK -
K7B67_RS09895 2545215..2546369 + 1155 WP_252180172.1 TraB/VirB10 family protein -
K7B67_RS09900 2546388..2546783 + 396 WP_252180173.1 TraV family lipoprotein -
K7B67_RS09905 2546798..2547136 + 339 WP_252180174.1 TraA family conjugative transfer protein -
K7B67_RS09910 2547139..2548335 + 1197 WP_252180175.1 TraI domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2428018..2550960 122942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-114)

Antitoxin

SinI-like, DNA-binding domain

(82-128)


Sequences

Toxin        


Download         Length: 191 a.a.        Molecular weight: 21796.92 Da        Isoelectric Point: 5.2789

>T215541 WP_252180167.1 NZ_CP082909:c2542981-2542409 [Endozoicomonas sp. 4G]
MASQFTAVFDACVLYPSVLRDVLLRLAITDTFRARWTDKIHDEWTRNLKANRPDIDENYLNKTRQLMNVHVRDALVEGFE
HLIDSVQLPDQDDRHVVAAAISANADVIVTYNLKDFPDEALAPYELQAIHPDSFIHDLIDLHPAEFIGVIRSARAALKNP
PLTVDEYLGRLRKQRLPETVTWLESMKLIL

Download         Length: 573 bp

>T215541 NZ_CP110814:845056-845463 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 153 a.a.        Molecular weight: 16878.20 Da        Isoelectric Point: 5.2538

>AT215541 WP_252180168.1 NZ_CP082909:c2543439-2542981 [Endozoicomonas sp. 4G]
MTTKDKLTLPTAEEIAIAQECSREISAFLETGSESQQIDISSKDGEKHALSIPTRALSLLVDILAQLGQGNAVKIIPIHA
ELTTQQAADILNVSRPYLVRMLDEGEIPHHKVGRHRRVRYQDLMDYKAAIDGKRLSALDELSALSQMNDPEY

Download         Length: 459 bp

>AT215541 NZ_CP110814:844809-845075 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References