Detailed information of TA system TA215539

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 2280473..2281272
• Replicon: chromosome
• Accession: NZ_CP082909
• Organism: Endozoicomonas sp. 4G

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: -
• Locus tag: K7B67_RS08875
• Protein ID: WP_252179990.1
• Coordinates: 2280473..2280997 (-)
• Length: 175 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: -
• Locus tag: K7B67_RS08880
• Protein ID: WP_252179991.1
• Coordinates: 2280994..2281272 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K7B67_RS08855	2275582..2276721	+	1140	WP_252179986.1	efflux RND transporter periplasmic adaptor subunit	-
K7B67_RS08860	2276718..2279819	+	3102	WP_252179987.1	efflux RND transporter permease subunit	-
K7B67_RS08865	2279916..2280119	+	204	WP_256484812.1	type II toxin-antitoxin system RelE/ParE family toxin	-
K7B67_RS08870	2280131..2280448	+	318	WP_252179989.1	HigA family addiction module antitoxin	-
K7B67_RS08875	2280473..2280997	-	525	WP_252179990.1	GNAT family N-acetyltransferase	Toxin
K7B67_RS08880	2280994..2281272	-	279	WP_252179991.1	DUF1778 domain-containing protein	Antitoxin
K7B67_RS08885	2281437..2282291	-	855	WP_252179992.1	EamA family transporter	-
K7B67_RS08890	2282371..2282889	+	519	WP_252179993.1	MarR family transcriptional regulator	-
K7B67_RS08895	2282942..2283457	+	516	WP_252179994.1	MFS transporter	-
K7B67_RS08900	2283417..2284094	+	678	WP_252179995.1	MFS transporter	-
K7B67_RS08905	2284232..2284537	-	306	WP_252179996.1	helix-turn-helix transcriptional regulator	-
K7B67_RS08910	2284509..2284877	-	369	WP_252179997.1	type II toxin-antitoxin system RelE/ParE family toxin	-
K7B67_RS08915	2285376..2286212	-	837	WP_252179998.1	UTP--glucose-1-phosphate uridylyltransferase GalU	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (11-88)

Sequences

Toxin

Protein

• Length: 175 a.a.
• Molecular weight: 18845.67 Da
• Isoelectric Point: 9.3299

>T215539 WP_252179990.1 NZ_CP082909:c2280997-2280473 [Endozoicomonas sp. 4G]
MTLPIWHEEPIGKHHDRSAFDCGDGSLNQFLYRHARQSHEKGGAKTYLAISEHNEKILGYYSLSPASIAYERAPEVIKRG
LARHDVPVFRLGRLAVDTSVQGHGLAGQLLLAAGRRCLLVAAQAGGVALLIDAKNERVAGWYASYGAVPLLDAQLSLLLP
FKTIHAALTTAGKL

Nucleotide

• Length: 525 bp

>T215539 NZ_CP110814:651425-651739 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10337.99 Da
• Isoelectric Point: 4.8047

>AT215539 WP_252179991.1 NZ_CP082909:c2281272-2280994 [Endozoicomonas sp. 4G]
MPQIPVETNDRMSLRIASDEKSLLMRAAALQHTNLTEFVLRNVMSVARKIIEENERLELTEIDSLHVLDLLDNPPAPNDK
LMAAAFAMPKPS

Nucleotide

• Length: 279 bp

>AT215539 NZ_CP110814:651736-652152 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA