Detailed information of TA system TA215535

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1673224..1673873
• Replicon: chromosome
• Accession: NZ_CP082909
• Organism: Endozoicomonas sp. 4G

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: K7B67_RS06500
• Protein ID: WP_252179543.1
• Coordinates: 1673457..1673873 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: K7B67_RS06495
• Protein ID: WP_252179542.1
• Coordinates: 1673224..1673457 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K7B67_RS06470	1669060..1669671	+	612	WP_252179538.1	phosphoribosylanthranilate isomerase	-
K7B67_RS06475	1669668..1670882	+	1215	WP_252179539.1	tryptophan synthase subunit beta	-
K7B67_RS06480	1670900..1671703	+	804	WP_252180542.1	tryptophan synthase subunit alpha	-
K7B67_RS06485	1671795..1672724	+	930	WP_252179540.1	acetyl-CoA carboxylase, carboxyltransferase subunit beta	-
K7B67_RS06490	1672889..1673119	-	231	WP_252179541.1	hypothetical protein	-
K7B67_RS06495	1673224..1673457	+	234	WP_252179542.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
K7B67_RS06500	1673457..1673873	+	417	WP_252179543.1	PIN domain-containing protein	Toxin
K7B67_RS06505	1673956..1674207	-	252	WP_252179544.1	hypothetical protein	-
K7B67_RS06510	1674270..1675892	-	1623	WP_252179545.1	IS1182 family transposase	-
K7B67_RS06515	1676054..1676365	-	312	WP_252179546.1	DUF2442 domain-containing protein	-
K7B67_RS06520	1676358..1676624	-	267	WP_252179547.1	DUF4160 domain-containing protein	-
K7B67_RS06525	1676768..1677025	-	258	WP_252179548.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
K7B67_RS06530	1677085..1677528	-	444	WP_252179549.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-126)

Antitoxin

• SpoVT-AbrB domain (6-53)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15695.04 Da
• Isoelectric Point: 6.6344

>T215535 WP_252179543.1 NZ_CP082909:1673457-1673873 [Endozoicomonas sp. 4G]
MKYLLDTNVLIHILRGHDKGSIKEHFKSNNGRMFISAVTVDELMFGICCAPKRLREKKQEELNTLLSVIPILDFNEDAAE
HSSQIRYFLKSTGQLIGSYDNMIAGHARSLELTVITNNTKEFCRVPGLEVEDWSQPLT

Nucleotide

• Length: 417 bp

>T215535 NZ_CP110812:1378472-1379218 [Bacillus paralicheniformis]
ATGCTGCTATTTTATCAATTCCTTGTTTGGCTCATTGTTTTGGCGCTGGCTCTGTATGTGGCTGCCGTGTGGCGTTTTGA
AAAAAAGCTCACCGAAAAAACGGTCGCGATCCGAAAAACGTGGTACCTGCTTTATGTTATCGGCGCCGTGATTTATTGGA
CGCACGATCCGCAGTCGATTTTCACGAACCCGCTTCATTACCTGATCGTTGCCGTTTTTTTCACGCTGACAGACGCTTTT
ATTTTCTTAAACGCCTACTTTAAAAAGCTCGGCAGCTCCGAACTCGCGACAGACACAAGAATGCTTCTCGAAGAAAACAA
CGACCTCCTCCACACGTATCAAAACAGGCTGAAAACGTTTCAATACCTATTGAAAAACGAACCGATCCACATCTATTATG
GAAATATAGAAGCGTATGCAGAAGGGATCGAAAAGCTCATCAAACGGTTTGCCGAAAAAATGAATATATCCGCTGCACTT
TGCGAATATAATTCAGAAGAAAGCAAGGATCATTTGCTTGAGCATATGGAAAACCGATTCGATGTTCAAGAAAAGCTTGA
GCGCAAAGACGTTTATTATGAAGAAAACGGAAAAATGGTCCTCATTCCTTTTTCCATCCACGATTTTGACTATGTCATGA
AGTTAACCTCAGAAGACCTTGTCACAGAATTTGACTACCTCCTGTTTACTTCTTTAACAAGCATCTATGATCTTCTGCTA
CCAAACGAAGAGGAAGGTGACAACTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 9125.18 Da
• Isoelectric Point: 4.5388

>AT215535 WP_252179542.1 NZ_CP082909:1673224-1673457 [Endozoicomonas sp. 4G]
MKTTIFKNNRTQAVRIPKEFAFPENVKHVQIQRQGNTLTISPVDVDWDEFFDNITVCPDYPEREQPLPQERDFGDWS

Nucleotide

• Length: 234 bp

>AT215535 NZ_CP110812:1379218-1379391 [Bacillus paralicheniformis]
ATGGAGCCTGCTTTTCAGCAAGACCAGGAAAGCGCAAAAACGCGCCTCGCCTTTAAAATGTTTAAAAAGCAATCCAAAAC
CAATATCGCGAAATACGAAGTCAGCCCCCATACCGAACGGATTTTCCGGCAAAACGAACGGCTGATCGGCGAGTATAAAA
GAAAAAAAGCTTAA