Detailed information of TA system TA021553

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/couple_hipB(antitoxin)
• Location: 498202..498624
• Replicon: chromosome
• Accession: NC_007954
• Organism: Shewanella denitrificans OS217

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: SDEN_RS20450
• Protein ID: WP_157599815.1
• Coordinates: 498454..498624 (+)
• Length: 57 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: SDEN_RS02265
• Protein ID: WP_011494886.1
• Coordinates: 498202..498450 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SDEN_RS02240 (Sden_0422)	493528..495165	+	1638	WP_011494881.1	chaperonin GroEL	-
SDEN_RS02245 (Sden_0423)	495624..496205	+	582	WP_011494882.1	hypothetical protein	-
SDEN_RS02255 (Sden_0425)	496341..497500	+	1160	WP_086022092.1	IS3-like element ISSde6 family transposase	-
SDEN_RS02260 (Sden_0426)	497477..497833	-	357	WP_011494885.1	Abi family protein	-
SDEN_RS02265 (Sden_0427)	498202..498450	+	249	WP_011494886.1	helix-turn-helix domain-containing protein	Antitoxin
SDEN_RS20450	498454..498624	+	171	WP_157599815.1	hypothetical protein	Toxin
SDEN_RS02270	498624..498803	+	180	WP_157599816.1	hypothetical protein	-
SDEN_RS02275 (Sden_0429)	498966..500912	-	1947	WP_011494887.1	GGDEF domain-containing phosphodiesterase	-
SDEN_RS02280 (Sden_0430)	500909..502507	-	1599	WP_011494888.1	diguanylate cyclase	-
SDEN_RS02285 (Sden_0431)	502500..502937	-	438	WP_011494889.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (15-68)

Sequences

Toxin

Protein

• Length: 57 a.a.
• Molecular weight: 6250.94 Da
• Isoelectric Point: 4.6805

>T21553 WP_157599815.1 NC_007954:498454-498624 [Shewanella denitrificans OS217]
MSTSATLTLDMHLGDQIIGELSFDPATETFTVHYTHDWQQRGFPISPQSLACHGPY

Nucleotide

• Length: 171 bp

>T21553 NC_007954:498454-498624 [Shewanella denitrificans OS217]
ATGAGCACATCGGCAACACTGACGTTGGACATGCACCTGGGCGATCAAATTATCGGTGAGCTGTCATTTGACCCCGCGAC
TGAGACATTCACTGTTCATTACACTCATGATTGGCAGCAAAGGGGCTTCCCTATTTCGCCGCAGAGCTTAGCTTGCCACG
GGCCTTATTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8747.15 Da
• Isoelectric Point: 9.0317

>AT21553 WP_011494886.1 NC_007954:498202-498450 [Shewanella denitrificans OS217]
MALSLNQALNQGSLGLLVKETRNKAALTQEVAAMLCGVTKKTLIRVEKGEDVYISTVFKILNGLGINIVAGQHSDANASG
WY

Nucleotide

• Length: 249 bp

>AT21553 NC_007954:498202-498450 [Shewanella denitrificans OS217]
ATGGCACTTTCACTCAATCAAGCACTCAATCAAGGATCCTTGGGGTTACTGGTTAAAGAAACCCGAAACAAAGCGGCACT
GACGCAAGAGGTGGCGGCAATGCTGTGTGGGGTGACGAAGAAGACCTTGATCCGCGTCGAAAAAGGCGAAGATGTTTATA
TCTCAACTGTGTTTAAAATCCTTAATGGCCTGGGGATCAACATTGTGGCGGGACAGCATAGTGATGCTAACGCGAGTGGC
TGGTACTAA