Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 2630882..2631472 Replicon chromosome
Accession NZ_CP082904
Organism Mixta hanseatica isolate X22927

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag K6958_RS12695 Protein ID WP_249891441.1
Coordinates 2630882..2631214 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag K6958_RS12700 Protein ID WP_249891442.1
Coordinates 2631215..2631472 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6958_RS12675 (K6958_12675) 2627219..2628121 + 903 WP_249891438.1 LysR substrate-binding domain-containing protein -
K6958_RS12680 (K6958_12680) 2628206..2628703 + 498 WP_249891439.1 pyridoxamine 5'-phosphate oxidase family protein -
K6958_RS12685 (K6958_12685) 2628771..2630219 - 1449 WP_249891440.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
K6958_RS12695 (K6958_12695) 2630882..2631214 - 333 WP_249891441.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
K6958_RS12700 (K6958_12700) 2631215..2631472 - 258 WP_249891442.1 antitoxin Antitoxin
K6958_RS12705 2631820..2631999 - 180 WP_249891443.1 helix-turn-helix domain-containing protein -
K6958_RS12710 (K6958_12710) 2632065..2632325 + 261 Protein_2489 IS3 family transposase -
K6958_RS12715 (K6958_12715) 2632384..2632815 + 432 WP_249891444.1 DUF1795 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11836.66 Da        Isoelectric Point: 10.1839

>T215525 WP_249891441.1 NZ_CP082904:c2631214-2630882 [Mixta hanseatica]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTNGGNFARAAGFTVSLDDAGTKTTGVIRCDQPRTI
DMGARNGKRLERIPDAVVNEVLARLEAILS

Download         Length: 333 bp

>T215525 NZ_CP110809:c1111223-1110819 [Pseudomonas syringae]
ATGCTCAAGTACATGCTTGACACCAATATTTGCATTTTCACTATAAAGAACAAGCCAACTTCGGTGCGTGAAGCCTTCAA
CCTCCATCATGGACAGCTATGTATCAGCGCGATCACGTTGATGGAGCTTGTCTACGGCGCAGAAAAGTCTTTGAGCCCCG
AAAGAAACCTTGCCGTTGTAGAGGGTTTCACAGCGCGTCTTGAAGTGCTCCCTTACGACAGCGACGCTGCGGCTCATACC
GGCATGATCAGAGCCGAACTGGCTAGATCGGGCACACCGATCGGCCCGTACGATCAAATGATTGCAGGACACGCCCGCTC
TCTAGGCCTGGTGGTGATCACTAATAATCAGCGTGAATTCCGACGCGTCGAGGGGCTACGAGTAGAAGACTGGGTAAGCC
AGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9441.93 Da        Isoelectric Point: 4.4620

>AT215525 WP_249891442.1 NZ_CP082904:c2631472-2631215 [Mixta hanseatica]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWINAPAV
GKEIL

Download         Length: 258 bp

>AT215525 NZ_CP110809:c1111453-1111223 [Pseudomonas syringae]
ATGGAACAATCCACAGTCTTCAAAAGCAATCGAAGCCAGGCTGTCCGACTGCCAAAAGCGGTCGCCTTGCCAGACGACGT
GAAACGTGTCGATGTCGTAGCCGTGGGCAGAACCCGCATTATTTCCCCCGCCGGTGAAATGTGGAACAGCTGGTTCGATG
GTGAAAGTGTCAGTGATGATTTCATGGCAGAGCGTGAACAACCAGCCGAACAGCAGCGCGAATCGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References