Detailed information of TA system TA021552

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 341656..343244
• Replicon: chromosome
• Accession: NC_007954
• Organism: Shewanella denitrificans OS217

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: Q12SH4
• Locus tag: SDEN_RS01625
• Protein ID: WP_011494769.1
• Coordinates: 341937..343244 (+)
• Length: 436 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: SDEN_RS01620
• Protein ID: WP_011494768.1
• Coordinates: 341656..341937 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SDEN_RS01605 (Sden_0303)	338674..339672	+	999	WP_011494765.1	porphobilinogen synthase	-
SDEN_RS01610 (Sden_0304)	339669..340553	+	885	WP_041405631.1	EamA family transporter	-
SDEN_RS01615 (Sden_0305)	340617..341345	+	729	WP_011494767.1	ester cyclase	-
SDEN_RS01620 (Sden_0306)	341656..341937	+	282	WP_011494768.1	helix-turn-helix domain-containing protein	Antitoxin
SDEN_RS01625 (Sden_0307)	341937..343244	+	1308	WP_011494769.1	type II toxin-antitoxin system HipA family toxin	Toxin
SDEN_RS01630 (Sden_0308)	343856..347116	-	3261	WP_011494770.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 436 a.a.
• Molecular weight: 48656.17 Da
• Isoelectric Point: 7.9093

>T21552 WP_011494769.1 NC_007954:341937-343244 [Shewanella denitrificans OS217]
MAVLDVYMNGYLVGEFTKSSTGSHQFAYAPQWLAIPGSRPISLSMPLRKQAYKGDEVYNFFDNLLPDNLEVRNRVVARHN
ADSTHAFDLLAKIGQDSVGALQLIPHGQTPFDVKKIESKPLSEKQLEKVLKGYQSNIPLGMLADDDDFRISIAGAQEKTA
LLKLNGQWRLPIKSTPTTHIIKLPIGEINSHSHSINMSDSVENEYLCMMIVREFGLDAPECSIIKVGDIKALAVERFDRR
LSSDGQWIMRLPQEDFCQALNIPPAKKYESHGGPGIEQIMPYLLGSMNSERDRVNFIKSQVLFWLLAATDGHAKNFSLFI
EADGGYRLTPFYDILSMYPVIGGKGLNIRDAKLAMGFKATKGKKYQINQIFPRHFIQTAKAVGFDTGIMMEMMHDIADKV
EAVVVKVKAQLPDDFPAHIRDSILSGLTDRVKRIA

Nucleotide

• Length: 1308 bp

>T21552 NC_007954:341937-343244 [Shewanella denitrificans OS217]
ATGGCAGTGCTCGATGTTTATATGAATGGCTACCTTGTGGGTGAATTTACCAAATCATCCACAGGCTCTCATCAGTTTGC
GTATGCCCCGCAGTGGTTAGCGATACCCGGTAGTCGCCCAATTTCTTTGTCTATGCCGCTACGCAAGCAAGCTTATAAAG
GTGATGAAGTTTATAACTTCTTCGATAATTTGCTACCTGATAATCTCGAAGTGAGAAACAGAGTCGTTGCTCGTCATAAT
GCTGATTCGACCCATGCGTTTGACCTACTGGCTAAAATTGGTCAAGACAGTGTGGGTGCATTACAGCTTATCCCCCATGG
TCAGACTCCCTTTGATGTAAAAAAGATTGAGTCTAAACCGCTATCCGAAAAGCAGTTGGAAAAAGTACTCAAGGGTTATC
AGTCAAATATCCCCTTAGGCATGTTAGCCGATGACGATGACTTTAGGATTTCTATTGCCGGTGCCCAAGAAAAGACGGCA
TTACTTAAACTCAATGGACAGTGGCGACTGCCTATCAAATCGACACCCACGACCCATATTATTAAGCTGCCCATAGGTGA
AATAAACAGCCACTCCCACAGCATAAATATGTCTGACAGCGTCGAAAACGAATACCTGTGCATGATGATAGTCAGAGAGT
TTGGATTAGATGCACCCGAGTGCTCAATAATCAAAGTGGGTGATATTAAAGCGCTTGCTGTGGAGCGATTCGATCGCAGG
CTCTCGTCTGATGGTCAATGGATTATGCGGCTGCCCCAAGAAGACTTTTGTCAGGCATTAAATATTCCACCAGCGAAAAA
ATATGAGAGCCATGGTGGCCCGGGTATTGAACAAATTATGCCTTATCTATTGGGTTCGATGAACTCAGAGCGAGACAGAG
TTAACTTCATCAAGTCCCAGGTTTTGTTTTGGCTTTTAGCCGCAACCGATGGCCATGCTAAAAACTTCTCACTGTTCATT
GAGGCCGATGGCGGATATCGACTAACGCCTTTTTACGATATTTTATCCATGTACCCTGTTATTGGCGGTAAAGGCTTAAA
TATTCGCGATGCCAAGCTTGCGATGGGGTTCAAGGCGACGAAAGGTAAGAAATATCAAATCAACCAAATTTTCCCACGGC
ACTTTATCCAAACCGCTAAAGCTGTGGGCTTTGATACTGGGATTATGATGGAGATGATGCACGACATTGCTGACAAGGTA
GAGGCTGTGGTTGTGAAGGTTAAGGCGCAGCTGCCAGATGATTTTCCAGCGCACATACGGGATTCAATATTGAGCGGATT
AACTGACAGAGTTAAGCGCATAGCTTAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10639.09 Da
• Isoelectric Point: 8.5843

>AT21552 WP_011494768.1 NC_007954:341656-341937 [Shewanella denitrificans OS217]
MKVTNAKQLSTYLKDARLNAQLSQSKVASKVGIRQDTVSSFELNPDSTKLETLFKILSALNLELDIKVRNPQLVDERRHG
NATVPEQEWKEEW

Nucleotide

• Length: 282 bp

>AT21552 NC_007954:341656-341937 [Shewanella denitrificans OS217]
ATGAAGGTGACCAACGCAAAGCAGCTTAGTACGTATCTAAAAGATGCGCGACTGAATGCGCAGCTCTCGCAAAGCAAGGT
GGCGAGCAAGGTCGGTATTCGCCAGGATACAGTGTCAAGCTTTGAGCTGAACCCAGATTCGACCAAATTAGAAACGCTGT
TTAAGATCCTCTCTGCATTAAACCTAGAGCTAGATATAAAGGTTAGAAATCCACAGCTGGTGGATGAGCGCCGCCATGGT
AACGCCACAGTGCCTGAGCAAGAATGGAAGGAGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: Q12SH4