Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1256950..1257576 Replicon chromosome
Accession NZ_CP082904
Organism Mixta hanseatica isolate X22927

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag K6958_RS06005 Protein ID WP_249893808.1
Coordinates 1256950..1257168 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag K6958_RS06010 Protein ID WP_085067696.1
Coordinates 1257196..1257576 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6958_RS05975 (K6958_05990) 1252922..1253260 + 339 WP_007886947.1 P-II family nitrogen regulator -
K6958_RS05980 (K6958_05995) 1253297..1254580 + 1284 WP_249893804.1 ammonium transporter AmtB -
K6958_RS05985 (K6958_06000) 1254632..1255492 - 861 WP_249893805.1 acyl-CoA thioesterase II -
K6958_RS05990 (K6958_06005) 1255709..1256263 + 555 WP_249893806.1 YbaY family lipoprotein -
K6958_RS05995 (K6958_06010) 1256294..1256602 - 309 WP_249893807.1 MGMT family protein -
K6958_RS06005 (K6958_06020) 1256950..1257168 - 219 WP_249893808.1 HHA domain-containing protein Toxin
K6958_RS06010 (K6958_06025) 1257196..1257576 - 381 WP_085067696.1 Hha toxicity modulator TomB Antitoxin
K6958_RS06015 (K6958_06030) 1257725..1258078 - 354 WP_249893809.1 hypothetical protein -
K6958_RS06020 (K6958_06035) 1258428..1258568 - 141 WP_249893810.1 type B 50S ribosomal protein L36 -
K6958_RS06025 (K6958_06040) 1258584..1258841 - 258 WP_249893811.1 type B 50S ribosomal protein L31 -
K6958_RS06030 (K6958_06045) 1259083..1262232 - 3150 WP_249893812.1 multidrug efflux RND transporter permease subunit AcrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8701.16 Da        Isoelectric Point: 8.8578

>T215516 WP_249893808.1 NZ_CP082904:c1257168-1256950 [Mixta hanseatica]
MTEKLMTKTDYLMRLRRCRSIDTLERVIEKNKYELPDDELAVFYSAADHRLAELTMNKLYDKVPVSVWKYVR

Download         Length: 219 bp

>T215516 NZ_CP110806:4103077-4103418 [Cellulomonas sp. S1-8]
GTGATCGACCGTGGCTCCGTCTGCTGGGTCGACTTCGGCGAACCCCGGGGCAGCGAACCCGGCAAGCAGCGCCCGGCGGT
CGTGGTCCAGGCCGACGACTTCAACCGTTCGGCCATCGGCACCGTCGTGGTGGTCCCTCTGACCTCGAACACGTCGCTCG
CAGCGGTGCCGGGCAACGTGTTCGTCCCGCGCGTCGCCTCGGGACTCGCCAAGGACTCCGTCGCGAACGTCTCCCAGGTC
ACCGTGGCGTCGCGCGAGTACGTCACGTACCCCGTCGCCTCCTTGCCTGCGGACCTCGTCGCGGCGATCGACGACGGCCT
GCGCCTGGTGCTCGCGCTGTGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 14727.33 Da        Isoelectric Point: 4.2930

>AT215516 WP_085067696.1 NZ_CP082904:c1257576-1257196 [Mixta hanseatica]
MDEYSPKRHDIAQLNFLCENLYDESMATLGDSHHGWVNDPTSASNLQLNDLIEHIASFTMNYKIKHAEDEDLIVQIDDYL
DDTFMLFSNYGINVQDLQRWQRSARRLFNLFAEECAQLPLQPSHSF

Download         Length: 381 bp

>AT215516 NZ_CP110806:4102838-4103080 [Cellulomonas sp. S1-8]
ATGAAGACGGCCATCTCGCTTCCCGACCACGTCGCGGCCCGCATCGACGCCAGCGCGCGGCGGCACGGGATGACGCGTTC
CGAGTTCTACCGCCGCGCCGCCGAGCGGTACGCCACCGAGCTCGAGCGCTCCGACGTGACGGCGCGCATCGATGCGGCCA
TCAGGACCGGCGGCCAGCCCGCCGCCGACTCCGCACCCTTCCGCAGCCACGCAGCCGACGTCATCACCCAGGACGAGTGG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References