Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1162160..1162737 Replicon chromosome
Accession NZ_CP082904
Organism Mixta hanseatica isolate X22927

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag K6958_RS05515 Protein ID WP_249893720.1
Coordinates 1162160..1162492 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag K6958_RS05520 Protein ID WP_249893721.1
Coordinates 1162486..1162737 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6958_RS05510 (K6958_05525) 1161757..1162134 + 378 WP_249893719.1 hypothetical protein -
K6958_RS05515 (K6958_05530) 1162160..1162492 - 333 WP_249893720.1 endoribonuclease MazF Toxin
K6958_RS05520 (K6958_05535) 1162486..1162737 - 252 WP_249893721.1 antitoxin MazE Antitoxin
K6958_RS05525 (K6958_05540) 1163006..1163215 + 210 WP_249893722.1 DUF1471 domain-containing protein -
K6958_RS05530 (K6958_05545) 1163586..1164617 + 1032 WP_249893723.1 cell division protein ZapE -
K6958_RS05535 (K6958_05550) 1164788..1165645 + 858 WP_249893724.1 glucose 1-dehydrogenase -
K6958_RS05540 (K6958_05555) 1165693..1166514 - 822 WP_249893725.1 Cof-type HAD-IIB family hydrolase -
K6958_RS05545 (K6958_05560) 1166698..1167087 - 390 WP_249893726.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-101)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12147.04 Da        Isoelectric Point: 8.0519

>T215515 WP_249893720.1 NZ_CP082904:c1162492-1162160 [Mixta hanseatica]
MVAKYVPDAGDVVWLHFDPQAGHEQAGHRPALVLSAKQYNEMVGLMVWCPMTTKIKGYPFEVQLDSQPGSAVLADQVKSL
DWRAREATKKGRVTAAELESVRVISRLLVG

Download         Length: 333 bp

>T215515 NZ_CP110806:c3729500-3729195 [Cellulomonas sp. S1-8]
ATGCGCCCGATCCACGTCGCGCAGCTCGACAAGGCGCGGCCCGTCCTCGTCCTCACGCGGGAGCTGGTGCGCCCGCACCT
GTCGAACGTCACCGTCGCCCCGATCACGAGCACGATCCGCGGGCTGTCGACCGAGGTGCCGCTGGGGCCGGTCAACGGTC
TCGACCACGACTGCGTCGCGAGCTGCGACAACCTGCAGACCGTGCCGGTGTCCGCGCTGGGACGGCTGGTGGGGTACCTG
CTGCCGGACCAGGAGGCGCGCCTCGCGCTGGCGATCGCGCTGGCGTTCGACCTGGAGCCGGGGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9097.39 Da        Isoelectric Point: 4.3611

>AT215515 WP_249893721.1 NZ_CP082904:c1162737-1162486 [Mixta hanseatica]
MRQTIKRWGNSPAVRIPSQLMAAMALDVDAEVEVNVVFGSDNRPQLVIEPVTPAPTLEALLAKVTPENIHSEAFTDEVGK
EAW

Download         Length: 252 bp

>AT215515 NZ_CP110806:c3729742-3729500 [Cellulomonas sp. S1-8]
ATGACGATCCAGATCACCGTGCGGCTCGACGACGACCTCGTCGAGGCCGTCGACGCGCTCGTCGCCTCCGGGAGGGCGCG
CAGCCGCGCGTCGGTCGTCGAGGTCGCCCTCGAGCGACACCTGCGCCGGGAGCTGGCCGCGCGCGACGTCGAGATCCTGC
GCGGGGACGTGGCGTCCGGCGGTGACCTCGACGGGCTCGCCGCGTGGGCCCAGCAGCTGCCCGCGTCGGCGCAGCTCGAC
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References