Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 844045..844702 Replicon chromosome
Accession NZ_CP082898
Organism Klebsiella aerogenes strain KAE3SP

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag K6006_RS04115 Protein ID WP_015369792.1
Coordinates 844292..844702 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag K6006_RS04110 Protein ID WP_032709107.1
Coordinates 844045..844311 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6006_RS04085 (K6006_04080) 839272..840705 - 1434 WP_032712496.1 6-phospho-beta-glucosidase BglA -
K6006_RS04090 (K6006_04085) 840825..841553 - 729 WP_015369788.1 MurR/RpiR family transcriptional regulator -
K6006_RS04095 (K6006_04090) 841604..841915 + 312 WP_015703422.1 N(4)-acetylcytidine aminohydrolase -
K6006_RS04100 (K6006_04095) 842080..842739 + 660 WP_008806429.1 hemolysin III family protein -
K6006_RS04105 (K6006_04100) 842838..843821 - 984 WP_032709108.1 tRNA-modifying protein YgfZ -
K6006_RS04110 (K6006_04105) 844045..844311 + 267 WP_032709107.1 FAD assembly factor SdhE Antitoxin
K6006_RS04115 (K6006_04110) 844292..844702 + 411 WP_015369792.1 protein YgfX Toxin
K6006_RS04120 (K6006_04115) 844710..845231 - 522 WP_015369793.1 flavodoxin FldB -
K6006_RS04125 (K6006_04120) 845332..846228 + 897 WP_015703420.1 site-specific tyrosine recombinase XerD -
K6006_RS04130 (K6006_04125) 846251..846964 + 714 WP_015369795.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K6006_RS04135 (K6006_04130) 846970..848703 + 1734 WP_015369796.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-132)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T215504 WP_015369792.1 NZ_CP082898:844292-844702 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

>T215504 NZ_CP110791:2441003-2441287 [Yersinia sp. SCPM-O-B-9106 (C-191)]
ATGACTTATAATCTTGATTTTGATCGCCGGGCGCTAAAGGAATGGCATAAGCTCGGCGATACCGTACGCCAGCAATTTAA
GAAAAAGCTGCTCGAAGTGATTAAAAATCCACGCGTTGAAGCCAATAAACTGCGCGACTTACCTGATTGTTACAAAATAA
AACTACGCAGCGCCGGATACCGCCTGATTTATCAGGTGCAAGACGAAAAAATCACGGTTTTTGTGGTTGCCGTGGGTAAA
CGGGATCGTGAAGAAGCCTACAGTGAAGCTGGCAATCGCGTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10609.12 Da        Isoelectric Point: 5.6963

>AT215504 WP_032709107.1 NZ_CP082898:844045-844311 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADTQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT215504 NZ_CP110791:2440774-2441013 [Yersinia sp. SCPM-O-B-9106 (C-191)]
ATGGGTAACATTAATATTCGCATTGATGATGACTTAAAAGATCGTTCTTATGCGGTACTGGAAAAGCTGGGGGTCACCCC
CTCTGATTTGCTGCGCCAGACACTGGAATATGTGGCACAAAGTGGCAAACTGCCCTTTAAATCCGTGTTGCTGACCGATG
AAGATCAAGCACTGGTCGCCGTAGTCAGAGAACGTTTAGCCAATCCACAACCGGTCAGGGTGTCACTGGATGACTTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52


Antitoxin

Source ID Structure

References