Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
| Location | 320496..321082 | Replicon | chromosome |
| Accession | NZ_CP082898 | ||
| Organism | Klebsiella aerogenes strain KAE3SP | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | K6006_RS01510 | Protein ID | WP_032709318.1 |
| Coordinates | 320714..321082 (+) | Length | 123 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | W9B1V1 |
| Locus tag | K6006_RS01505 | Protein ID | WP_004174006.1 |
| Coordinates | 320496..320717 (+) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6006_RS01485 (K6006_01485) | 316637..317563 | + | 927 | WP_015369323.1 | high-affinity branched-chain amino acid ABC transporter permease LivH | - |
| K6006_RS01490 (K6006_01490) | 317560..318837 | + | 1278 | WP_223575775.1 | branched chain amino acid ABC transporter permease LivM | - |
| K6006_RS01495 (K6006_01495) | 318834..319601 | + | 768 | WP_196338495.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG | - |
| K6006_RS01500 (K6006_01500) | 319619..320332 | + | 714 | WP_086538103.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF | - |
| K6006_RS01505 (K6006_01505) | 320496..320717 | + | 222 | WP_004174006.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| K6006_RS01510 (K6006_01510) | 320714..321082 | + | 369 | WP_032709318.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| K6006_RS01515 (K6006_01515) | 321374..322690 | + | 1317 | WP_015703703.1 | sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB | - |
| K6006_RS01520 (K6006_01520) | 322797..323684 | + | 888 | WP_015369328.1 | sn-glycerol-3-phosphate ABC transporter permease UgpA | - |
| K6006_RS01525 (K6006_01525) | 323681..324526 | + | 846 | WP_015369329.1 | sn-glycerol-3-phosphate ABC transporter permease UgpE | - |
| K6006_RS01530 (K6006_01530) | 324528..325598 | + | 1071 | WP_032709316.1 | sn-glycerol-3-phosphate import ATP-binding protein UgpC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 315474..326335 | 10861 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13552.97 Da Isoelectric Point: 9.7753
>T215503 WP_032709318.1 NZ_CP082898:320714-321082 [Klebsiella aerogenes]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGKLTLEQIVARLRG
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGKLTLEQIVARLRG
Download Length: 369 bp
>T215503 NZ_CP110791:2279166-2279624 [Yersinia sp. SCPM-O-B-9106 (C-191)]
ATGAAGTTCTACCGTATTGTGATGCGCCGTTATCTGGCGTCAACCTGGACCGGTTATGGCGCCGAAATCTATGGTGGCCG
TTGGAATCATAAGGGGCACGCCGCCATCTACTTAGCCAGCAGTGTGTCTTTGGCGATGCTGGAAACATTGGTGCATATCC
AAGACAGCTCAACGCTGAGCGAGTTCGAGCTATTCCAGATTGAAATCGAAGATAGCCATATTCTGTTACTTCAGCCGCAA
GATTGGCCTGCTGACTGGCGCAGTGATCCCGCGCCGGCGACCACAATGGATATCGGCACCGAATGGTTAGAGCTGGAATC
ATCACTTGCATTACTGGTTCCATCCACTCTGGTGCCGTCAGAAAACAATCTACTGCTCAACCCTCGGCATAAAGATTTTC
AAGCTTGCTTAAACAGTGTTAAACCACTCTCTTTTGCCTTTGACCCACGGCTGAAATAG
ATGAAGTTCTACCGTATTGTGATGCGCCGTTATCTGGCGTCAACCTGGACCGGTTATGGCGCCGAAATCTATGGTGGCCG
TTGGAATCATAAGGGGCACGCCGCCATCTACTTAGCCAGCAGTGTGTCTTTGGCGATGCTGGAAACATTGGTGCATATCC
AAGACAGCTCAACGCTGAGCGAGTTCGAGCTATTCCAGATTGAAATCGAAGATAGCCATATTCTGTTACTTCAGCCGCAA
GATTGGCCTGCTGACTGGCGCAGTGATCCCGCGCCGGCGACCACAATGGATATCGGCACCGAATGGTTAGAGCTGGAATC
ATCACTTGCATTACTGGTTCCATCCACTCTGGTGCCGTCAGAAAACAATCTACTGCTCAACCCTCGGCATAAAGATTTTC
AAGCTTGCTTAAACAGTGTTAAACCACTCTCTTTTGCCTTTGACCCACGGCTGAAATAG
Antitoxin
Download Length: 74 a.a. Molecular weight: 8151.15 Da Isoelectric Point: 4.7769
>AT215503 WP_004174006.1 NZ_CP082898:320496-320717 [Klebsiella aerogenes]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK
Download Length: 222 bp
>AT215503 NZ_CP110791:2278634-2279080 [Yersinia sp. SCPM-O-B-9106 (C-191)]
ATGAGAGCATATCACCCGACCCCAGCGACCAAAACTGGGGCGCTATGGCGAGAGATTGGTTTGCCCGCCAGCCGCGGCAC
TGTATTGGTCGATAGTATCAAAATGGGTTTTTCAGTTGATGTTATTGACGGCATCCATTTATGGGCTTCTATCCCTAAAG
CTGAAATATTGCGGGCCACGGGTATTCCCAGCCGCAGTCTGACCCGTAGACGCACACATGATGGCCGTTTCACCCCTGAA
GAGAGTGAGCGAATTGCCCGTTTCGTCCGGGTAATGGATGCCGCAGTTGATCTATTTGGCGGTGATAAGGGCAAAGCTAT
CGCCTGGATGTCTACCCCGATTAAAGGTCTTGGTCACCGCAGCCCCGACTCCTTGCTGGAAACGGAAACCGGTGCACTGG
AAGTCTGTGATTTAATTGGGCGTTTGGAGCACGGCGTATTTTCATAA
ATGAGAGCATATCACCCGACCCCAGCGACCAAAACTGGGGCGCTATGGCGAGAGATTGGTTTGCCCGCCAGCCGCGGCAC
TGTATTGGTCGATAGTATCAAAATGGGTTTTTCAGTTGATGTTATTGACGGCATCCATTTATGGGCTTCTATCCCTAAAG
CTGAAATATTGCGGGCCACGGGTATTCCCAGCCGCAGTCTGACCCGTAGACGCACACATGATGGCCGTTTCACCCCTGAA
GAGAGTGAGCGAATTGCCCGTTTCGTCCGGGTAATGGATGCCGCAGTTGATCTATTTGGCGGTGATAAGGGCAAAGCTAT
CGCCTGGATGTCTACCCCGATTAAAGGTCTTGGTCACCGCAGCCCCGACTCCTTGCTGGAAACGGAAACCGGTGCACTGG
AAGTCTGTGATTTAATTGGGCGTTTGGAGCACGGCGTATTTTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|