215500

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 2435..3023 Replicon plasmid p2016LNAB1-3
Accession NZ_CP082893
Organism Acinetobacter baumannii strain 2016LNAB1

Toxin (Protein)


Gene name brnT Uniprot ID A0A0J8TIH5
Locus tag H1I71_RS20060 Protein ID WP_000438827.1
Coordinates 2435..2722 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag H1I71_RS20065 Protein ID WP_001983304.1
Coordinates 2709..3023 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1I71_RS20045 127..1062 + 936 WP_001292329.1 replication initiation protein RepM -
H1I71_RS20050 1140..1658 + 519 WP_000839337.1 plasmid replication DNA-binding protein -
H1I71_RS20055 1868..2167 + 300 WP_000358348.1 hypothetical protein -
H1I71_RS20060 2435..2722 + 288 WP_000438827.1 BrnT family toxin Toxin
H1I71_RS20065 2709..3023 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
H1I71_RS20070 3151..5562 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
H1I71_RS20075 5867..6328 + 462 WP_000761346.1 DIP1984 family protein -
H1I71_RS20080 6654..6863 - 210 WP_000069474.1 hypothetical protein -
H1I71_RS20085 6856..7158 - 303 WP_001129974.1 XRE family transcriptional regulator -
H1I71_RS20090 7151..7507 - 357 WP_000269904.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11205 11205


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11329.75 Da        Isoelectric Point: 5.6762

>T215500 WP_000438827.1 NZ_CP082893:2435-2722 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRYTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T215500 NZ_CP110791:c386274-385918 [Yersinia sp. SCPM-O-B-9106 (C-191)]
ATGAAACCACGCGCCACAGCGCAGGATGCATTGCCCGTGCCTGTTATTTATCAGCAACTGCTCGCTTTTCTGCTGGAGCA
CCACTATGGCCTGAGCCTCAACGATACGCCCTATCACGATGAACAGATTATTACACAGCAGATAGAACAAGGGATTTCAG
TCGGCGACACCATCAACACACTGGTTGAGAAGTATGCATTAGTGCGAATTGGTCGTAACGGGTTCAGCGCACTGGTACAA
GACCCGATGCTGAGTAAGGGCGATATCGCCCGTGCTCGCCAGGCCGCAGGTCTGTGGCGTGCGCATTTTCCGCCAACGTT
GCTGTACCCAACCGAGTCCCTCAATCCTATTCAATAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT215500 WP_001983304.1 NZ_CP082893:2709-3023 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT215500 NZ_CP110791:c385906-385574 [Yersinia sp. SCPM-O-B-9106 (C-191)]
ATGAATAACCACATTACGACTTCCCCAACATGGGGCCTGAAACGTGATATTACGCCGCGGTTAGGGGCCCGACTGGTTCA
GGAGGGAACGCATCTGCATTTTCTGAGCGACAGAGCCCACATTGTCGGCACCTTTTCCCCTCAAGCCACTCAGGTTCTTG
ATGCAGCGTTTCCCGCGCTGATAACCAAACTAGAATCGCAACTGCTGTCCGGAGCGCTGGATCCACGCCGTCAGCAGTGC
CTTACGGTCCGGCACGGGGAATTTGTCTGTGAAGCGGATACGCTGGGTAGTCACGGCTATGTCTATATCGCGGTGTATCA
AGAACTGTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TIH5

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References